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Abdom Radiol (NY). 2016 Sep;41(9):1811-24. doi: 10.1007/s00261-016-0744-5.

MR imaging features of focal liver lesions in Wilson disease.

Author information

1
UMR INSERM 965, Hôpital Lariboisière, 2 Rue Amboise Paré, 75010, Paris, France.
2
Azienda Ospedaliera Universitaria, Seconda Università degli Studi di Napoli, Naples, Italy.
3
Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 Rue Ambroise Paré, 75475, Paris Cedex 10, France.
4
CNR Wilson - Service de Neurologie Hôpital Lariboisière, 2 Rue Ambroise Paré, 75475, Paris Cedex 10, France.
5
Department of Radiology, Centre Pierre et Marie Curie, Place du 1er Mai, 16016, Alger, Algeria.
6
UMR INSERM 965, Hôpital Lariboisière, 2 Rue Amboise Paré, 75010, Paris, France. philippe.soyer@aphp.fr.
7
Department of Body and Interventional Imaging, Hôpital Lariboisière, AP-HP, 2 Rue Ambroise Paré, 75475, Paris Cedex 10, France. philippe.soyer@aphp.fr.
8
Université Paris-Diderot, Sorbonne-Paris Cité, 10 Rue de Verdun, 75010, Paris, France. philippe.soyer@aphp.fr.

Abstract

Hepatic involvement in Wilson disease (WD) manifests as a diffuse chronic disease in the majority of patients. However, in a subset of patients focal liver lesions may develop, presenting with a wide range of imaging features. The majority of focal liver lesions in patients with WD are benign nodules, but there are reports that have described malignant liver tumors or dysplastic nodules in these patients. Because of the possibility of malignant transformation of liver nodules, major concerns have been raised with respect to the management and follow-up of patients with WD in whom focal liver lesions have been identified. The assessment of liver involvement in patients with WD is generally performed with ultrasonography. However, ultrasonography conveys limited specificity so that magnetic resonance (MR) imaging is often performed to improve lesion characterization. This review was performed to illustrate the spectrum of MR imaging features of focal liver lesions that develop in patients with WD. It is assumed that familiarity with the MR imaging presentation of focal liver lesions in WD may help clarify the actual nature of hepatic nodules in patients with this condition.

KEYWORDS:

Chronic liver disease; Liver MRI; Liver nodules; Magnetic resonance imaging; Wilson disease

PMID:
27116011
DOI:
10.1007/s00261-016-0744-5
[Indexed for MEDLINE]

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