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Euro Surveill. 2017 May 4;22(18). pii: 30529. doi: 10.2807/1560-7917.ES.2017.22.18.30529.

Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART.

Author information

1
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States.
2
Becton Dickinson, Research Triangle Park, North Carolina, United States.
3
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
4
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
5
Biomedical Advanced Research and Development Authority (BARDA), Washington DC, United States.

Abstract

A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.

KEYWORDS:

air-borne infections; influenza virus; surveillance; viral infections

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