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Items: 15


Why the need and how to approach the functional diversity of extracellular vesicles.

Tkach M, Kowal J, Théry C.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). pii: 20160479. doi: 10.1098/rstb.2016.0479. Review.


Qualitative differences in T-cell activation by dendritic cell-derived extracellular vesicle subtypes.

Tkach M, Kowal J, Zucchetti AE, Enserink L, Jouve M, Lankar D, Saitakis M, Martin-Jaular L, Théry C.

EMBO J. 2017 Oct 16;36(20):3012-3028. doi: 10.15252/embj.201696003. Epub 2017 Sep 18.


A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses.

Coria LM, Ibañez AE, Tkach M, Sabbione F, Bruno L, Carabajal MV, Berguer PM, Barrionuevo P, Schillaci R, Trevani AS, Giambartolomei GH, Pasquevich KA, Cassataro J.

J Immunol. 2016 May 15;196(10):4014-29. doi: 10.4049/jimmunol.1501188. Epub 2016 Apr 15.


Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.

Tkach M, Théry C.

Cell. 2016 Mar 10;164(6):1226-1232. doi: 10.1016/j.cell.2016.01.043. Review.


Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes.

Kowal J, Arras G, Colombo M, Jouve M, Morath JP, Primdal-Bengtson B, Dingli F, Loew D, Tkach M, Théry C.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77. doi: 10.1073/pnas.1521230113. Epub 2016 Feb 8.


Transmission of innate immune signaling by packaging of cGAMP in viral particles.

Gentili M, Kowal J, Tkach M, Satoh T, Lahaye X, Conrad C, Boyron M, Lombard B, Durand S, Kroemer G, Loew D, Dalod M, Théry C, Manel N.

Science. 2015 Sep 11;349(6253):1232-6. doi: 10.1126/science.aab3628. Epub 2015 Jul 30.


Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth.

Izzo F, Mercogliano F, Venturutti L, Tkach M, Inurrigarro G, Schillaci R, Cerchietti L, Elizalde PV, Proietti CJ.

Breast Cancer Res. 2014 Dec 6;16(6):491. doi: 10.1186/s13058-014-0491-x.


Biogenesis and secretion of exosomes.

Kowal J, Tkach M, Théry C.

Curr Opin Cell Biol. 2014 Aug;29:116-25. doi: 10.1016/ Epub 2014 Jun 22. Review.


Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy.

Díaz Flaqué MC, Galigniana NM, Béguelin W, Vicario R, Proietti CJ, Russo R, Rivas MA, Tkach M, Guzmán P, Roa JC, Maronna E, Pineda V, Muñoz S, Mercogliano M, Charreau EH, Yankilevich P, Schillaci R, Elizalde PV.

Breast Cancer Res. 2013 Dec 17;15(6):R118. doi: 10.1186/bcr3587.


p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth.

Tkach M, Rosemblit C, Rivas MA, Proietti CJ, Díaz Flaqué MC, Mercogliano MF, Beguelin W, Maronna E, Guzmán P, Gercovich FG, Deza EG, Elizalde PV, Schillaci R.

Endocr Relat Cancer. 2013 Mar 22;20(2):197-212. doi: 10.1530/ERC-12-0194. Print 2013 Apr.


Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells.

Tkach M, Coria L, Rosemblit C, Rivas MA, Proietti CJ, Díaz Flaqué MC, Beguelin W, Frahm I, Charreau EH, Cassataro J, Elizalde PV, Schillaci R.

J Immunol. 2012 Aug 1;189(3):1162-72. doi: 10.4049/jimmunol.1102538. Epub 2012 Jun 29.


Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model.

Durfort T, Tkach M, Meschaninova MI, Rivas MA, Elizalde PV, Venyaminova AG, Schillaci R, François JC.

PLoS One. 2012;7(1):e29213. doi: 10.1371/journal.pone.0029213. Epub 2012 Jan 3.


Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer.

Proietti CJ, Béguelin W, Flaqué MC, Cayrol F, Rivas MA, Tkach M, Charreau EH, Schillaci R, Elizalde PV.

Steroids. 2011 Mar;76(4):381-92. doi: 10.1016/j.steroids.2010.12.008. Epub 2010 Dec 22. Erratum in: Steroids. 2011 Nov;76(12):1407.


Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3.

Béguelin W, Díaz Flaqué MC, Proietti CJ, Cayrol F, Rivas MA, Tkach M, Rosemblit C, Tocci JM, Charreau EH, Schillaci R, Elizalde PV.

Mol Cell Biol. 2010 Dec;30(23):5456-72. doi: 10.1128/MCB.00012-10. Epub 2010 Sep 27.


Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.

Rivas MA, Tkach M, Beguelin W, Proietti CJ, Rosemblit C, Charreau EH, Elizalde PV, Schillaci R.

Breast Cancer Res Treat. 2010 Jul;122(1):111-24. doi: 10.1007/s10549-009-0546-3. Epub 2009 Sep 18.


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