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Curr Opin Struct Biol. 2013 Apr;23(2):292-301. doi: 10.1016/j.sbi.2013.04.002. Epub 2013 Apr 27.

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

Abstract

Ca(2+)/calmodulin dependent protein kinase II (CaMKII) is a broadly distributed metazoan Ser/Thr protein kinase that is important in neuronal and cardiac signaling. CaMKII forms oligomeric assemblies, typically dodecameric, in which the calcium-responsive kinase domains are organized around a central hub. We review the results of crystallographic analyses of CaMKII, including the recently determined structure of a full-length and autoinhibited form of the holoenzyme. These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies.

PMID:
23632248
PMCID:
PMC3788167
DOI:
10.1016/j.sbi.2013.04.002
[Indexed for MEDLINE]
Free PMC Article

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