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Lupus. 2016 Sep;25(10):1080-5. doi: 10.1177/0961203316652493.

T-cell-directed therapies in systemic lupus erythematosus.

Author information

1
Division of Rheumatology, Northwell Health, Great Neck, NY, USA pnandkumar@northwell.edu.
2
Division of Rheumatology, Northwell Health, Great Neck, NY, USA.

Abstract

Drug development for the treatment of systemic lupus erythematosus (SLE) has largely focused on B-cell therapies. A greater understanding of the immunopathogenesis of SLE coupled with advanced bioengineering has allowed for clinical trials centered on other targets for SLE therapy. The authors discuss the benefits and shortcomings of focusing on T-cell-directed therapies in SLE and lupus nephritis clinical trials.

KEYWORDS:

Systemic lupus erythematosus; T-cell therapy; clinical trials; lupus nephritis; treatment

PMID:
27497252
DOI:
10.1177/0961203316652493
[Indexed for MEDLINE]

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