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See 1 citation in Nature Chemical Biology 2011 by Luciani:

Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Author information

1
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Erratum in

  • Nat Chem Biol. 2012 Mar;8(3):318.

Abstract

The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.

PMID:
22057127
DOI:
10.1038/nchembio.698
[Indexed for MEDLINE]

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