Cytotoxic constituents from Butea superba Roxb

J Ethnopharmacol. 2007 Jan 19;109(2):354-8. doi: 10.1016/j.jep.2006.07.034. Epub 2006 Aug 4.

Abstract

A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Butea / chemistry*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • Isoflavones / chemistry
  • Isoflavones / pharmacology
  • Medicine, East Asian Traditional
  • Pterocarpans* / chemistry
  • Pterocarpans* / pharmacology
  • Thailand

Substances

  • Antineoplastic Agents, Phytogenic
  • Isoflavones
  • Pterocarpans
  • prunetin
  • formononetin
  • medicarpin