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J Natl Cancer Inst. 2018 Apr 1;110(4):426-429. doi: 10.1093/jnci/djx206.

Long-term Safety of Pregnancy Following Breast Cancer According to Estrogen Receptor Status.

Author information

1
Department of Medicine, Institut Jules Bordet and Université Libre de Bruxelles (ULB), Brussels, Belgium.
2
Department of Breast Surgery, University Hospital Herlev, Copenhagen, Denmark.
3
Data Centre, Institut Jules Bordet and Université Libre de Bruxelles (ULB), Brussels, Belgium.
4
Vall D'Hebron University Hospital, Barcelona, Spain.
5
La Paz University Hospital, Madrid, Spain.
6
Macerata Hospital, Macerata, Italy.
7
Danish Breast Cancer Group, Rigshospitalet, Copenhagen, Denmark.
8
International Breast Cancer Study Group Statistical Centre, Dana-Farber Cancer Institute, Boston, MA.
9
Department of Internal Medicine, American University of Beirut (AUB), Beirut, Lebanon.
10
European Institute of Oncology, Milan, Italy.

Abstract

Safety of pregnancy in women with history of estrogen receptor (ER)-positive breast cancer remains controversial. In this multicenter case-control study, 333 patients with pregnancy after breast cancer were matched (1:3) to 874 nonpregnant patients of similar characteristics, adjusting for guaranteed time bias. Survival estimates were calculated using the Kaplan-Meier analysis; groups were compared with the log-rank test. All reported P values were two-sided. At a median follow-up of 7.2 years after pregnancy, no difference in disease-free survival was observed between pregnant and nonpregnant patients with ER-positive (hazard ratio [HR] = 0.94, 95% confidence interval [CI] = 0.70 to 1.26, P = .68) or ER-negative (HR = 0.75, 95% CI = 0.53 to 1.06, P = .10) disease. No overall survival (OS) difference was observed in ER-positive patients (HR = 0.84, 95% CI = 0.60 to 1.18, P = .32); ER-negative patients in the pregnant cohort had better OS (HR = 0.57, 95% CI = 0.36 to 0.90, P = .01). Abortion, time to pregnancy, breastfeeding, and type of adjuvant therapy had no impact on patients' outcomes. This study provides reassuring evidence on the long-term safety of pregnancy in breast cancer survivors, including those with ER-positive disease.

PMID:
29087485
DOI:
10.1093/jnci/djx206
[Indexed for MEDLINE]

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