Format

Send to

Choose Destination

See 1 citation found by title matching your search:

BMJ. 2018 May 30;361:k1998. doi: 10.1136/bmj.k1998.

Long term survival, health, social functioning, and education in patients with European Lyme neuroborreliosis: nationwide population based cohort study.

Author information

1
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, DK-2100, Copenhagen, Denmark niels.obel@regionh.dk.
2
Department of Clinical Microbiology, Slagelse Hospital, Slagelse, Denmark.
3
Bacteria, Parasites and Fungi Department, Statens Serum Institute, Copenhagen, Denmark.
4
Department of Clinical Microbiology and Infectious Diseases, Aalborg University hospital, Aalborg, Denmark.
5
Clinical Center for Emerging and Vector-borne Infections, Odense University Hospital, Odense, Denmark.
6
Department of Clinical Microbiology, Vejle Hospital, Vejle, Denmark.
7
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, DK-2100, Copenhagen, Denmark.
8
Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
9
Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
10
Department of Clinical Microbiology, Herlev University Hospital, Copenhagen, Denmark.
11
Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
12
Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark.
13
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
14
Department of Epidemiology, Boston University, Boston, MA, USA.
15
Department of Clinical Microbiology, Hvidovre University Hospital, Copenhagen, Denmark.

Abstract

OBJECTIVE:

To estimate long term survival, health, and educational/social functioning in patients with Lyme neuroborreliosis compared with the general population.

DESIGN:

Nationwide population based cohort study using national registers.

SETTING:

Denmark.

PARTICIPANTS:

All Danish residents diagnosed during 1986-2016 as having Lyme neuroborreliosis (n=2067), defined as a positive Borrelia burgdorferi intrathecal antibody test and a clinical diagnosis of Lyme borreliosis, and a comparison cohort from the general population matched on sex and date of birth (n=20 670).

MAIN OUTCOME MEASURES:

Mortality rate ratios, incidence rate ratios of comorbidities, and differences in educational and social outcomes.

RESULTS:

Mortality among patients with Lyme neuroborreliosis was not higher than in the general population (mortality rate ratio 0.90, 95% confidence interval 0.79 to 1.03). Lyme neuroborreliosis patients had increased risk of haematological (incidence rate ratio 3.07, 2.03 to 4.66) and non-melanoma skin cancers (1.49, 1.18 to 1.88). At diagnosis, Lyme neuroborreliosis patients had slightly higher employment and lower disability pension rates. After five years, patients and comparison cohort members had similar numbers of hospital contacts (difference -0.22, 95% confidence interval -0.45 to 0.02, in-hospital days/year; 0.37, -0.10 to 0.83, outpatient visits/year), employment rates (difference 1.5%, -2.1% to 5.1%), income (difference -1000, -20 000 to 18 000, Danish kroner), days of sick leave (difference -0.3, -3.5 to 3.0, per year), rates of receipt of a disability pension (difference -0.9%, -3.2% to 1.3%), and number of children (difference -0.10, -0.27 to 0.08). More patients were married (difference 4.8%, 2.2% to 7.4%) and had completed high school education (difference 7%, 1% to 12%).

CONCLUSION:

A verified diagnosis of Lyme neuroborreliosis had no substantial effect on long term survival, health, or educational/social functioning. Nevertheless, the diagnosis decreased labour market involvement marginally and was associated with increased risk of haematological and non-melanoma skin cancers.

PMID:
29848547
PMCID:
PMC5974636
DOI:
10.1136/bmj.k1998
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center