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Page 1
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell. 2018 Jan 25;172(3):578-589.e17. doi: 10.1016/j.cell.2018.01.006.
Cell. 2018.
PMID: 29373830
Free article.
Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators.
Martinborough E, Shen Y, Oeveren Av, Long YO, Lau TL, Marschke KB, Chang WY, López FJ, Vajda EG, Rix PJ, Viveros OH, Negro-Vilar A, Zhi L.
Martinborough E, et al. Among authors: long yo.
J Med Chem. 2007 Oct 18;50(21):5049-52. doi: 10.1021/jm070231h. Epub 2007 Sep 21.
J Med Chem. 2007.
PMID: 17887661
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Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.
Lelais G, Epple R, Marsilje TH, Long YO, McNeill M, Chen B, Lu W, Anumolu J, Badiger S, Bursulaya B, DiDonato M, Fong R, Juarez J, Li J, Manuia M, Mason DE, Gordon P, Groessl T, Johnson K, Jia Y, Kasibhatla S, Li C, Isbell J, Spraggon G, Bender S, Michellys PY.
Lelais G, et al. Among authors: long yo.
J Med Chem. 2016 Jul 28;59(14):6671-89. doi: 10.1021/acs.jmedchem.5b01985. Epub 2016 Jul 19.
J Med Chem. 2016.
PMID: 27433829
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Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity.
Long YO, Higuchi RI, Caferro TR, Lau TL, Wu M, Cummings ML, Martinborough EA, Marschke KB, Chang WY, López FJ, Karanewsky DS, Zhi L.
Long YO, et al.
Bioorg Med Chem Lett. 2008 May 1;18(9):2967-71. doi: 10.1016/j.bmcl.2008.03.062. Epub 2008 Mar 23.
Bioorg Med Chem Lett. 2008.
PMID: 18400499
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Concise total syntheses of the bioactive mesotricyclic diterpenoids jatrophatrione and citlalitrione.
Yang J, Long YO, Paquette LA.
Yang J, et al. Among authors: long yo.
J Am Chem Soc. 2003 Feb 12;125(6):1567-74. doi: 10.1021/ja021177r.
J Am Chem Soc. 2003.
PMID: 12568617
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Concerning the antileukemic agent jatrophatrione: the first total synthesis of a [5.9.5] tricyclic diterpene.
Paquette LA, Yang J, Long YO.
Paquette LA, et al. Among authors: long yo.
J Am Chem Soc. 2002 Jun 12;124(23):6542-3. doi: 10.1021/ja020292z.
J Am Chem Soc. 2002.
PMID: 12047168
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Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.
Higuchi RI, Arienti KL, López FJ, Mani NS, Mais DE, Caferro TR, Long YO, Jones TK, Edwards JP, Zhi L, Schrader WT, Negro-Vilar A, Marschke KB.
Higuchi RI, et al. Among authors: long yo.
J Med Chem. 2007 May 17;50(10):2486-96. doi: 10.1021/jm061329j. Epub 2007 Apr 17.
J Med Chem. 2007.
PMID: 17439112
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