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PLoS One. 2014 Dec 10;9(12):e110393. doi: 10.1371/journal.pone.0110393. eCollection 2014.

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa.

Author information

1
Institute of Tropical Medicine (ITM), Antwerp, Belgium; Medical Research Council (MRC), The Gambia Unit, Fajara, The Gambia.
2
Institute of Tropical Medicine (ITM), Antwerp, Belgium.
3
Laboratoire de Reference des Mycobactéries, Cotonou, Benin.
4
Laboratoire des Mycobactéries, Institut Pasteur de Bangui, Bangui, Central African Republic.
5
Laboratoire de Reference des Mycobactéries, Conakry, Guinea-Conakry.
6
London School of Hygiene and Tropical Medicine, London, United Kingdom.
7
UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland.
8
Laboratoire de Reference des Mycobactéries, Dakar, Senegal.
9
National TB Programme, Dakar, Senegal.
10
Damien Foundation, Niamey, Niger.
11
Independent Consultant, Yaoundé, Cameroon.
12
Medical Research Council (MRC), The Gambia Unit, Fajara, The Gambia.
13
Institute of Tropical Medicine (ITM), Antwerp, Belgium; New York University, New York, United States of America.

Abstract

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.

PMID:
25493429
PMCID:
PMC4262193
DOI:
10.1371/journal.pone.0110393
[Indexed for MEDLINE]
Free PMC Article

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