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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V.

Aging Cell. 2019 Nov 6:e13057. doi: 10.1111/acel.13057. [Epub ahead of print]


Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model.

Hoffman JD, Yanckello LM, Chlipala G, Hammond TC, McCulloch SD, Parikh I, Sun S, Morganti JM, Green SJ, Lin AL.

PLoS One. 2019 Aug 28;14(8):e0221828. doi: 10.1371/journal.pone.0221828. eCollection 2019.


Blood Flow Deficits and Cerebrovascular Changes in a Dietary Model of Hyperhomocysteinemia.

Braun DJ, Abner E, Bakshi V, Goulding DS, Grau EM, Lin AL, Norris CM, Sudduth TL, Webster SJ, Wilcock DM, Van Eldik LJ.

ASN Neuro. 2019 Jan-Dec;11:1759091419865788. doi: 10.1177/1759091419865788. No abstract available.


Caloric Restriction Alters Postprandial Responses of Essential Brain Metabolites in Young Adult Mice.

Yanckello LM, Young LEA, Hoffman JD, Mohney RP, Keaton MA, Abner E, Lin AL.

Front Nutr. 2019 Jun 12;6:90. doi: 10.3389/fnut.2019.00090. eCollection 2019.


Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model.

Macheda T, Roberts K, Lyons DN, Higgins E, Ritter KJ, Lin AL, Alilain WJ, Bachstetter AD.

Neuroscience. 2019 Feb 1;398:55-63. doi: 10.1016/j.neuroscience.2018.11.040. Epub 2018 Dec 7.


Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer's Disease.

Lee J, Yanckello LM, Ma D, Hoffman JD, Parikh I, Thalman S, Bauer B, Hartz AMS, Hyder F, Lin AL.

Front Aging Neurosci. 2018 Jul 26;10:225. doi: 10.3389/fnagi.2018.00225. eCollection 2018. Review.


A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism.

Lyons DN, Vekaria H, Macheda T, Bakshi V, Powell DK, Gold BT, Lin AL, Sullivan PG, Bachstetter AD.

J Neurotrauma. 2018 Oct 15;35(20):2435-2447. doi: 10.1089/neu.2018.5663. Epub 2018 Jul 2.


Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice.

Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL.

Sci Rep. 2018 Apr 27;8(1):6670. doi: 10.1038/s41598-018-25190-5.


Age Drives Distortion of Brain Metabolic, Vascular and Cognitive Functions, and the Gut Microbiome.

Hoffman JD, Parikh I, Green SJ, Chlipala G, Mohney RP, Keaton M, Bauer B, Hartz AMS, Lin AL.

Front Aging Neurosci. 2017 Sep 25;9:298. doi: 10.3389/fnagi.2017.00298. eCollection 2017.


Neuroimaging Biomarkers of Caloric Restriction on Brain Metabolic and Vascular Functions.

Lin AL, Parikh I, Hoffman JD, Ma D.

Curr Nutr Rep. 2017 Mar;6(1):41-48. doi: 10.1007/s13668-017-0187-9.


Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images.

Guo S, Lai C, Wu C, Cen G; Alzheimer's Disease Neuroimaging Initiative.

Front Aging Neurosci. 2017 May 18;9:146. doi: 10.3389/fnagi.2017.00146. eCollection 2017. Erratum in: Front Aging Neurosci. 2017 Sep 05;9:293.


mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment.

Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.

J Cereb Blood Flow Metab. 2018 Jan;38(1):58-74. doi: 10.1177/0271678X17705973. Epub 2017 May 17.


Targeting mitochondrial dysfunction in CNS injury using Methylene Blue; still a magic bullet?

Vekaria HJ, Talley Watts L, Lin AL, Sullivan PG.

Neurochem Int. 2017 Oct;109:117-125. doi: 10.1016/j.neuint.2017.04.004. Epub 2017 Apr 7. Review.


Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.).

Kochunov P, Wey HY, Fox PT, Lancaster JL, Davis MD, Wang DJ, Lin AL, Bastarrachea RA, Andrade MC, Mattern V, Frost P, Higgins PB, Comuzzie AG, Voruganti VS.

Front Neurosci. 2017 Feb 14;11:49. doi: 10.3389/fnins.2017.00049. eCollection 2017.


Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions.

Parikh I, Guo J, Chuang KH, Zhong Y, Rempe RG, Hoffman JD, Armstrong R, Bauer B, Hartz AM, Lin AL.

Aging (Albany NY). 2016 Nov 8;8(11):2814-2826. doi: 10.18632/aging.101094.


mTOR: Alzheimer's disease prevention for APOE4 carriers.

Lin AL, Butterfield DA, Richardson A.

Oncotarget. 2016 Jul 19;7(29):44873-44874. doi: 10.18632/oncotarget.10349. No abstract available.


Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism.

Anderson KL, Frazier HN, Maimaiti S, Bakshi VV, Majeed ZR, Brewer LD, Porter NM, Lin AL, Thibault O.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):189-197. doi: 10.1093/gerona/glw065. Epub 2016 Apr 10.


Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.

Ighodaro ET, Abner EL, Fardo DW, Lin AL, Katsumata Y, Schmitt FA, Kryscio RJ, Jicha GA, Neltner JH, Monsell SE, Kukull WA, Moser DK, Appiah F, Bachstetter AD, Van Eldik LJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Nelson PT.

J Cereb Blood Flow Metab. 2017 Jan;37(1):201-216. Epub 2016 Jan 6.


Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease.

Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A.

J Cereb Blood Flow Metab. 2017 Jan;37(1):217-226. Epub 2015 Dec 31.

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