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Items: 1 to 20 of 23

1.

dCas9-Based Scn1a Gene Activation Restores Inhibitory Interneuron Excitability and Attenuates Seizures in Dravet Syndrome Mice.

Colasante G, Lignani G, Brusco S, Di Berardino C, Carpenter J, Giannelli S, Valassina N, Bido S, Ricci R, Castoldi V, Marenna S, Church T, Massimino L, Morabito G, Benfenati F, Schorge S, Leocani L, Kullmann DM, Broccoli V.

Mol Ther. 2019 Sep 3. pii: S1525-0016(19)30401-0. doi: 10.1016/j.ymthe.2019.08.018. [Epub ahead of print]

PMID:
31607539
2.

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.

Salpietro V, Dixon CL, Guo H, Bello OD, Vandrovcova J, Efthymiou S, Maroofian R, Heimer G, Burglen L, Valence S, Torti E, Hacke M, Rankin J, Tariq H, Colin E, Procaccio V, Striano P, Mankad K, Lieb A, Chen S, Pisani L, Bettencourt C, Männikkö R, Manole A, Brusco A, Grosso E, Ferrero GB, Armstrong-Moron J, Gueden S, Bar-Yosef O, Tzadok M, Monaghan KG, Santiago-Sim T, Person RE, Cho MT, Willaert R, Yoo Y, Chae JH, Quan Y, Wu H, Wang T, Bernier RA, Xia K, Blesson A, Jain M, Motazacker MM, Jaeger B, Schneider AL, Boysen K, Muir AM, Myers CT, Gavrilova RH, Gunderson L, Schultz-Rogers L, Klee EW, Dyment D, Osmond M, Parellada M, Llorente C, Gonzalez-Peñas J, Carracedo A, Van Haeringen A, Ruivenkamp C, Nava C, Heron D, Nardello R, Iacomino M, Minetti C, Skabar A, Fabretto A; SYNAPS Study Group, Raspall-Chaure M, Chez M, Tsai A, Fassi E, Shinawi M, Constantino JN, De Zorzi R, Fortuna S, Kok F, Keren B, Bonneau D, Choi M, Benzeev B, Zara F, Mefford HC, Scheffer IE, Clayton-Smith J, Macaya A, Rothman JE, Eichler EE, Kullmann DM, Houlden H.

Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w.

3.

Synapsin I Controls Synaptic Maturation of Long-Range Projections in the Lateral Amygdala in a Targeted Selective Fashion.

Lugarà E, De Fusco A, Lignani G, Benfenati F, Humeau Y.

Front Cell Neurosci. 2019 May 21;13:220. doi: 10.3389/fncel.2019.00220. eCollection 2019.

4.

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics.

Weston M, Kaserer T, Wu A, Mouravlev A, Carpenter JC, Snowball A, Knauss S, von Schimmelmann M, During MJ, Lignani G, Schorge S, Young D, Kullmann DM, Lieb A.

Sci Adv. 2019 Apr 17;5(4):eaaw1567. doi: 10.1126/sciadv.aaw1567. eCollection 2019 Apr.

5.

Neurite-Enriched MicroRNA-218 Stimulates Translation of the GluA2 Subunit and Increases Excitatory Synaptic Strength.

Rocchi A, Moretti D, Lignani G, Colombo E, Scholz-Starke J, Baldelli P, Tkatch T, Benfenati F.

Mol Neurobiol. 2019 Aug;56(8):5701-5714. doi: 10.1007/s12035-019-1492-7. Epub 2019 Jan 23.

PMID:
30671783
6.

Foamy Virus Vectors Transduce Visceral Organs and Hippocampal Structures following In Vivo Delivery to Neonatal Mice.

Counsell JR, Karda R, Diaz JA, Carey L, Wiktorowicz T, Buckley SMK, Ameri S, Ng J, Baruteau J, Almeida F, de Silva R, Simone R, Lugarà E, Lignani G, Lindemann D, Rethwilm A, Rahim AA, Waddington SN, Howe SJ.

Mol Ther Nucleic Acids. 2018 Sep 7;12:626-634. doi: 10.1016/j.omtn.2018.07.006. Epub 2018 Aug 3.

7.

REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity.

Pecoraro-Bisogni F, Lignani G, Contestabile A, Castroflorio E, Pozzi D, Rocchi A, Prestigio C, Orlando M, Valente P, Massacesi M, Benfenati F, Baldelli P.

Mol Neurobiol. 2018 Jun;55(6):4959-4972. doi: 10.1007/s12035-017-0698-9. Epub 2017 Aug 7.

PMID:
28786015
8.

Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating.

Liavas A, Lignani G, Schorge S.

J Physiol. 2017 Aug 15;595(16):5671-5685. doi: 10.1113/JP274693. Epub 2017 Jul 18.

9.

Gene therapy and editing: Novel potential treatments for neuronal channelopathies.

Wykes RC, Lignani G.

Neuropharmacology. 2018 Apr;132:108-117. doi: 10.1016/j.neuropharm.2017.05.029. Epub 2017 May 28. Review.

10.

Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.

Morris G, Leite M, Kullmann DM, Pavlov I, Schorge S, Lignani G.

J Neurosci. 2017 May 31;37(22):5484-5495. doi: 10.1523/JNEUROSCI.3697-16.2017. Epub 2017 May 4.

11.

Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels.

Valente P, Lignani G, Medrihan L, Bosco F, Contestabile A, Lippiello P, Ferrea E, Schachner M, Benfenati F, Giovedì S, Baldelli P.

J Cell Sci. 2016 May 1;129(9):1878-91. doi: 10.1242/jcs.182089. Epub 2016 Mar 16.

12.

Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

Colasante G, Lignani G, Rubio A, Medrihan L, Yekhlef L, Sessa A, Massimino L, Giannelli SG, Sacchetti S, Caiazzo M, Leo D, Alexopoulou D, Dell'Anno MT, Ciabatti E, Orlando M, Studer M, Dahl A, Gainetdinov RR, Taverna S, Benfenati F, Broccoli V.

Cell Stem Cell. 2015 Dec 3;17(6):719-734. doi: 10.1016/j.stem.2015.09.002. Epub 2015 Oct 29.

13.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Espinoza S, Lignani G, Caffino L, Maggi S, Sukhanov I, Leo D, Mus L, Emanuele M, Ronzitti G, Harmeier A, Medrihan L, Sotnikova TD, Chieregatti E, Hoener MC, Benfenati F, Tucci V, Fumagalli F, Gainetdinov RR.

Neuropsychopharmacology. 2015 Aug;40(9):2217-27. doi: 10.1038/npp.2015.65. Epub 2015 Mar 9.

14.

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.

Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V.

Stem Cell Reports. 2015 Jan 13;4(1):25-36. doi: 10.1016/j.stemcr.2014.12.002. Epub 2014 Dec 31.

15.

Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.

Orlando M, Lignani G, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedí S, Benfenati F.

J Neurosci. 2014 Oct 29;34(44):14752-68. doi: 10.1523/JNEUROSCI.1093-14.2014.

16.

Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.

Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F.

J Neurosci. 2014 May 21;34(21):7266-80. doi: 10.1523/JNEUROSCI.3973-13.2014.

17.

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.

Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D'Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P.

EMBO J. 2013 Nov 13;32(22):2994-3007. doi: 10.1038/emboj.2013.231. Epub 2013 Oct 22.

18.

Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity.

Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F.

Front Mol Neurosci. 2013 Aug 20;6:22. doi: 10.3389/fnmol.2013.00022. eCollection 2013.

19.

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.

Medrihan L, Cesca F, Raimondi A, Lignani G, Baldelli P, Benfenati F.

Nat Commun. 2013;4:1512. doi: 10.1038/ncomms2515.

20.

Presynaptic muscarinic receptors reduce synaptic depression and facilitate its recovery at hippocampal GABAergic synapses.

González JC, Lignani G, Maroto M, Baldelli P, Hernández-Guijo JM.

Cereb Cortex. 2014 Jul;24(7):1818-31. doi: 10.1093/cercor/bht032. Epub 2013 Feb 20.

PMID:
23425889

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