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Items: 1 to 20 of 23


Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression.

Adam RC, Yang H, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E.

Cell Stem Cell. 2018 Mar 1;22(3):398-413.e7. doi: 10.1016/j.stem.2017.12.004. Epub 2018 Jan 11.


Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells.

Veltri A, Lang C, Lien WH.

Stem Cells. 2018 Jan;36(1):22-35. doi: 10.1002/stem.2723. Epub 2017 Oct 31. Review.


Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.

Jossin Y, Lee M, Klezovitch O, Kon E, Cossard A, Lien WH, Fernandez TE, Cooper JA, Vasioukhin V.

Dev Cell. 2017 Jun 5;41(5):481-495.e5. doi: 10.1016/j.devcel.2017.05.002. Epub 2017 May 25.


αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.

Li P, Silvis MR, Honaker Y, Lien WH, Arron ST, Vasioukhin V.

Genes Dev. 2016 Apr 1;30(7):798-811. doi: 10.1101/gad.274951.115. Epub 2016 Mar 24.


Feedback regulation of apical progenitor fate by immature neurons through Wnt7-Celsr3-Fzd3 signalling.

Wang W, Jossin Y, Chai G, Lien WH, Tissir F, Goffinet AM.

Nat Commun. 2016 Mar 4;7:10936. doi: 10.1038/ncomms10936.


Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.

Lien WH, Fuchs E.

Genes Dev. 2014 Jul 15;28(14):1517-32. doi: 10.1101/gad.244772.114. Review.


Comparison of REST cistromes across human cell types reveals common and context-specific functions.

Rockowitz S, Lien WH, Pedrosa E, Wei G, Lin M, Zhao K, Lachman HM, Fuchs E, Zheng D.

PLoS Comput Biol. 2014 Jun 12;10(6):e1003671. doi: 10.1371/journal.pcbi.1003671. eCollection 2014 Jun.


In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.

Lien WH, Polak L, Lin M, Lay K, Zheng D, Fuchs E.

Nat Cell Biol. 2014 Feb;16(2):179-90. doi: 10.1038/ncb2903. Epub 2014 Jan 26.


Nfatc1 orchestrates aging in hair follicle stem cells.

Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo X, Oristian DS, Zheng D, Fuchs E.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4950-9. doi: 10.1073/pnas.1320301110. Epub 2013 Nov 26.


RNAi screens in mice identify physiological regulators of oncogenic growth.

Beronja S, Janki P, Heller E, Lien WH, Keyes BE, Oshimori N, Fuchs E.

Nature. 2013 Sep 12;501(7466):185-90. doi: 10.1038/nature12464. Epub 2013 Aug 14.


DNA methylation dynamics during in vivo differentiation of blood and skin stem cells.

Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A.

Mol Cell. 2012 Aug 24;47(4):633-47. doi: 10.1016/j.molcel.2012.06.019. Epub 2012 Jul 26.


Genome-wide maps of histone modifications unwind in vivo chromatin states of the hair follicle lineage.

Lien WH, Guo X, Polak L, Lawton LN, Young RA, Zheng D, Fuchs E.

Cell Stem Cell. 2011 Sep 2;9(3):219-32. doi: 10.1016/j.stem.2011.07.015.


α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1.

Silvis MR, Kreger BT, Lien WH, Klezovitch O, Rudakova GM, Camargo FD, Lantz DM, Seykora JT, Vasioukhin V.

Sci Signal. 2011 May 24;4(174):ra33. doi: 10.1126/scisignal.2001823.


EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.

Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E.

Genes Dev. 2011 Mar 1;25(5):485-98. doi: 10.1101/gad.2019811. Epub 2011 Feb 11.


An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.

Mendrysa SM, Akagi K, Roayaei J, Lien WH, Copeland NG, Jenkins NA, Eisenman RN.

Genes Cancer. 2010 May;1(5):465-479.


Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.

Lien WH, Gelfand VI, Vasioukhin V.

J Cell Biol. 2008 Dec 15;183(6):989-97. doi: 10.1083/jcb.200805041.


Dissecting the role of cadherin-catenin proteins in mammalian epidermis.

Lien WH, Stepniak E, Vasioukhin V.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15225-6. doi: 10.1073/pnas.0808458105. Epub 2008 Oct 1. No abstract available.


alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain.

Lien WH, Klezovitch O, Null M, Vasioukhin V.

J Cell Sci. 2008 May 1;121(Pt 9):1357-62. doi: 10.1242/jcs.020537. Epub 2008 Apr 8.


Cadherin-catenin proteins in vertebrate development.

Lien WH, Klezovitch O, Vasioukhin V.

Curr Opin Cell Biol. 2006 Oct;18(5):499-506. Epub 2006 Jul 21. Review.


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