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Items: 1 to 20 of 41


The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness.

Lacey JRN, Kidel C, van der Kaaij JM, Brinkman P, Gilbert-Kawai ET, Grocott MPW, Mythen MG, Martin DS; Xtreme Everest 2 Research Group.

Physiol Rep. 2018 Sep;6(17):e13854. doi: 10.14814/phy2.13854.


Sustained vasomotor control of skin microcirculation in Sherpas versus altitude-naive lowlanders: Experimental evidence from Xtreme Everest 2.

Davies T, Gilbert-Kawai E, Wythe S, Meale P, Mythen M, Levett D, Mitchell K, Grocott M, Clough G, Martin D; Xtreme Everest 2 Research Group.

Exp Physiol. 2018 Nov;103(11):1494-1504. doi: 10.1113/EP087236. Epub 2018 Sep 12.


TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans.

Capitanio D, Fania C, Torretta E, Viganò A, Moriggi M, Bravatà V, Caretti A, Levett DZH, Grocott MPW, Samaja M, Cerretelli P, Gelfi C.

Sci Rep. 2017 Aug 29;7(1):9723. doi: 10.1038/s41598-017-10097-4.


Exercise Testing, Supplemental Oxygen, and Hypoxia.

Ward SA, Grocott MPW, Levett DZH.

Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S140-S148. doi: 10.1513/AnnalsATS.201701-043OT. Review.


Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.

Wandrag L, Siervo M, Riley HL, Khosravi M, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZH, Montgomery HE, Mythen MG, Stroud MA, Grocott MPW, Feelisch M; Caudwell Xtreme Everest Research Group.

Redox Biol. 2017 Oct;13:60-68. doi: 10.1016/j.redox.2017.05.004. Epub 2017 May 8.


Metabolic basis to Sherpa altitude adaptation.

Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6382-6387. doi: 10.1073/pnas.1700527114. Epub 2017 May 22.


Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).

Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP, Swenson ER; Caudwell Xtreme Everest Investigators.

Exp Physiol. 2017 Jun 1;102(6):711-724. doi: 10.1113/EP086083. Epub 2017 May 21.


Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning.

Griva K, Stygall J, Wilson MH, Martin D, Levett D, Mitchell K, Mythen M, Montgomery HE, Grocott MP, Aref-Adib G, Edsell M, Plant T, Imray C, Cooke D, Harrington J, Khosravi M, Newman SP; Caudwell Xtreme Everest Research Group.

PLoS One. 2017 Mar 27;12(3):e0174277. doi: 10.1371/journal.pone.0174277. eCollection 2017.


Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.

Gilbert-Kawai E, Coppel J, Court J, van der Kaaij J, Vercueil A, Feelisch M, Levett D, Mythen M, Grocott MP, Martin D; Xtreme Everest 2 Research Group.

J Appl Physiol (1985). 2017 Apr 1;122(4):1011-1018. doi: 10.1152/japplphysiol.00970.2016. Epub 2017 Jan 26.


High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual.

Gilbert-Kawai E, Martin D, Grocott M, Levett D.

Extrem Physiol Med. 2016 Sep 14;5:10. doi: 10.1186/s13728-016-0051-3. eCollection 2016.


Caudwell Xtreme Everest: An Overview.

Grocott MP, Levett DZ, Martin DS, Wilson MH, Mackenney A, Dhillon S, Montgomery HE, Mythen MG, Mitchell K.

Adv Exp Med Biol. 2016;903:427-37. doi: 10.1007/978-1-4899-7678-9_28. Review.


A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes.

Gilbert-Kawai E, Coppel J, Bountziouka V, Ince C, Martin D; Caudwell Xtreme Everest and Xtreme Everest 2 Research Groups.

BMC Med Imaging. 2016 Jan 21;16:10. doi: 10.1186/s12880-015-0078-8.


Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia.

Gilbert-Kawai E, Sheperdigian A, Adams T, Mitchell K, Feelisch M, Murray A, Peters M, Gilbert-Kawai G, Montgomery H, Levett D, Kumar R, Mythen M, Grocott M, Martin D.

F1000Res. 2015 Apr 10;4:90. doi: 10.12688/f1000research.6297.1. eCollection 2015.


Genetic factors associated with exercise performance in atmospheric hypoxia.

Hennis PJ, O'Doherty AF, Levett DZ, Grocott MP, Montgomery HM.

Sports Med. 2015 May;45(5):745-61. doi: 10.1007/s40279-015-0309-8. Review.


Systemic oxygen extraction during exercise at high altitude.

Martin DS, Cobb A, Meale P, Mitchell K, Edsell M, Mythen MG, Grocott MP; Xtreme Alps Research Group.

Br J Anaesth. 2015 Apr;114(4):677-82. doi: 10.1093/bja/aeu404. Epub 2014 Dec 13.


Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest.

Levett DZ, Viganò A, Capitanio D, Vasso M, De Palma S, Moriggi M, Martin DS, Murray AJ, Cerretelli P, Grocott MP, Gelfi C.

Proteomics. 2015 Jan;15(1):160-71. doi: 10.1002/pmic.201400306. Epub 2014 Dec 4.


Effects of prolonged exposure to hypobaric hypoxia on oxidative stress, inflammation and gluco-insular regulation: the not-so-sweet price for good regulation.

Siervo M, Riley HL, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZ, Montgomery HE, Mythen MG, Grocott MP, Feelisch M; Caudwell Xtreme Everest Research Group.

PLoS One. 2014 Apr 14;9(4):e94915. doi: 10.1371/journal.pone.0094915. eCollection 2014.


Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP.

Holloway CJ, Murray AJ, Mitchell K, Martin DS, Johnson AW, Cochlin LE, Codreanu I, Dhillon S, Rodway GW, Ashmore T, Levett DZ, Neubauer S, Montgomery HE, Grocott MP, Clarke K; Caudwell Xtreme Everest 2009 Investigators.

High Alt Med Biol. 2014 Dec;15(4):459-67. doi: 10.1089/ham.2013.1053.


Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?

Martin DS, Gilbert-Kawai E, Levett DZh, Mitchell K, Kumar Bc R, Mythen MG, Grocott MP.

Extrem Physiol Med. 2013 Oct 23;2(1):30. doi: 10.1186/2046-7648-2-30.


The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude.

Martin DS, Levett DZ, Bezemer R, Montgomery HE, Grocott MP; Caudwell Xtreme Everest Research Group.

High Alt Med Biol. 2013 Sep;14(3):256-62. doi: 10.1089/ham.2012.1109.

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