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Items: 1 to 20 of 42

1.

Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations.

Manczinger M, Boross G, Kemény L, Müller V, Lenz TL, Papp B, Pál C.

PLoS Biol. 2019 Jan 31;17(1):e3000131. doi: 10.1371/journal.pbio.3000131. eCollection 2019 Jan.

2.

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control.

Arora J, McLaren PJ, Chaturvedi N, Carrington M, Fellay J, Lenz TL.

Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):944-949. doi: 10.1073/pnas.1812548116. Epub 2019 Jan 2.

PMID:
30602460
3.

Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles.

Degenhardt F, Wendorff M, Wittig M, Ellinghaus E, Datta LW, Schembri J, Ng SC, Rosati E, Hübenthal M, Ellinghaus D, Jung ES, Lieb W, Abedian S, Malekzadeh R, Cheon JH, Ellul P, Sood A, Midha V, Bk T, Wong SH, Schreiber S, Yamazaki K, Kubo M, Boucher G, Rioux J, Lenz TL, Brant SR, Franke A.

Hum Mol Genet. 2018 Dec 26. doi: 10.1093/hmg/ddy443. [Epub ahead of print]

PMID:
30590525
4.

Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors.

Hasan Ali O, Berner F, Bomze D, Fässler M, Diem S, Cozzio A, Jörger M, Früh M, Driessen C, Lenz TL, Flatz L.

Eur J Cancer. 2019 Jan;107:8-14. doi: 10.1016/j.ejca.2018.11.009. Epub 2018 Dec 7.

5.

Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes.

Lenz TL, Hafer N, Samonte IE, Yeates SE, Milinski M.

Evolution. 2018 Nov;72(11):2478-2490. doi: 10.1111/evo.13591. Epub 2018 Sep 24.

6.

Divergent allele advantage at human MHC genes: signatures of past and ongoing selection.

Pierini F, Lenz TL.

Mol Biol Evol. 2018 Jun 8. doi: 10.1093/molbev/msy116. [Epub ahead of print]

7.

Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans.

Krause-Kyora B, Nutsua M, Boehme L, Pierini F, Pedersen DD, Kornell SC, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Caliebe A, Nothnagel M, Schreiber S, Boldsen JL, Lenz TL, Nebel A.

Nat Commun. 2018 May 1;9(1):1569. doi: 10.1038/s41467-018-03857-x.

8.

Adaptive value of novel MHC immune gene variants.

Lenz TL.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1414-1416. doi: 10.1073/pnas.1722600115. Epub 2018 Jan 31. No abstract available.

9.

The One Past Health workshop: connecting ancient DNA and zoonosis research.

Calvignac-Spencer S, Lenz TL.

Bioessays. 2017 Jul;39(7). doi: 10.1002/bies.201700075. Epub 2017 Jun 8. No abstract available.

PMID:
28593700
10.

A field reciprocal transplant experiment reveals asymmetric costs of migration between lake and river ecotypes of three-spined sticklebacks (Gasterosteus aculeatus).

Kaufmann J, Lenz TL, Kalbe M, Milinski M, Eizaguirre C.

J Evol Biol. 2017 May;30(5):938-950. doi: 10.1111/jeb.13057. Epub 2017 Mar 15.

PMID:
28211194
11.

Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection.

Lenz TL, Spirin V, Jordan DM, Sunyaev SR.

Mol Biol Evol. 2016 Oct;33(10):2555-64. doi: 10.1093/molbev/msw127. Epub 2016 Jun 28.

12.

Genes with monoallelic expression contribute disproportionately to genetic diversity in humans.

Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA.

Nat Genet. 2016 Mar;48(3):231-237. doi: 10.1038/ng.3493. Epub 2016 Jan 25.

13.

Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks.

Huang Y, Chain FJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TB, Milinski M, Feulner PG.

Mol Ecol. 2016 Feb;25(4):943-58. doi: 10.1111/mec.13520. Epub 2016 Feb 9.

14.

Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.

McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay J.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14658-63. doi: 10.1073/pnas.1514867112. Epub 2015 Nov 9.

15.

Transcription in space--environmental vs. genetic effects on differential immune gene expression.

Lenz TL.

Mol Ecol. 2015 Sep;24(18):4583-5. doi: 10.1111/mec.13356.

PMID:
26374665
16.

Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.

Lenz TL, Deutsch AJ, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TW, Abecasis G, Becker J, Boeckxstaens GE, Chen WM, Franke A, Gladman DD, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää-Dahlqvist S, Stuart PE, Tsoi LC, van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen PK, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PI, Raychaudhuri S.

Nat Genet. 2015 Sep;47(9):1085-90. doi: 10.1038/ng.3379. Epub 2015 Aug 10.

17.

Correction: Genomics of Divergence along a Continuum of Parapatric Population Differentiation.

Feulner PG, Chain FJ, Panchal M, Huang Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TB, Milinski M.

PLoS Genet. 2015 Jul 30;11(7):e1005414. doi: 10.1371/journal.pgen.1005414. eCollection 2015 Jul. No abstract available.

18.

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.

Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, Raychaudhuri S.

Nat Genet. 2015 Aug;47(8):898-905. doi: 10.1038/ng.3353. Epub 2015 Jul 13.

19.

Genomics of divergence along a continuum of parapatric population differentiation.

Feulner PG, Chain FJ, Panchal M, Huang Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TB, Milinski M.

PLoS Genet. 2015 Feb 13;11(2):e1004966. doi: 10.1371/journal.pgen.1004966. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 Jul;11(7):e1005414.

20.

The contribution of post-copulatory mechanisms to incipient ecological speciation in sticklebacks.

Kaufmann J, Eizaguirre C, Milinski M, Lenz TL.

Biol Lett. 2015 Jan;11(1):20140933. doi: 10.1098/rsbl.2014.0933.

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