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Items: 1 to 20 of 33


Functional diversification of the NleG effector family in enterohemorrhagic Escherichia coli.

Valleau D, Little DJ, Borek D, Skarina T, Quaile AT, Di Leo R, Houliston S, Lemak A, Arrowsmith CH, Coombes BK, Savchenko A.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10004-10009. doi: 10.1073/pnas.1718350115. Epub 2018 Sep 14.


Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.

Houliston RS, Lemak A, Iqbal A, Ivanochko D, Duan S, Kaustov L, Ong MS, Fan L, Senisterra G, Brown PJ, Wang YX, Arrowsmith CH.

J Biol Chem. 2017 Dec 22;292(51):20947-20959. doi: 10.1074/jbc.M117.799700. Epub 2017 Oct 26.


Solution NMR structure of the TRIM21 B-box2 and identification of residues involved in its interaction with the RING domain.

Wallenhammar A, Anandapadamanaban M, Lemak A, Mirabello C, Lundström P, Wallner B, Sunnerhagen M.

PLoS One. 2017 Jul 28;12(7):e0181551. doi: 10.1371/journal.pone.0181551. eCollection 2017.


Global analysis of protein folding using massively parallel design, synthesis, and testing.

Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D.

Science. 2017 Jul 14;357(6347):168-175. doi: 10.1126/science.aan0693.


The second round of Critical Assessment of Automated Structure Determination of Proteins by NMR: CASD-NMR-2013.

Rosato A, Vranken W, Fogh RH, Ragan TJ, Tejero R, Pederson K, Lee HW, Prestegard JH, Yee A, Wu B, Lemak A, Houliston S, Arrowsmith CH, Kennedy M, Acton TB, Xiao R, Liu G, Montelione GT, Vuister GW.

J Biomol NMR. 2015 Aug;62(4):413-24. doi: 10.1007/s10858-015-9953-4. Epub 2015 Jun 14.


Structural characterization of a flexible two-domain protein in solution using small angle X-ray scattering and NMR data.

Lemak A, Wu B, Yee A, Houliston S, Lee HW, Gutmanas A, Fang X, Garcia M, Semesi A, Wang YX, Prestegard JH, Arrowsmith CH.

Structure. 2014 Dec 2;22(12):1862-1874. doi: 10.1016/j.str.2014.09.013. Epub 2014 Nov 6.


Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO.

Eletsky A, Michalska K, Houliston S, Zhang Q, Daily MD, Xu X, Cui H, Yee A, Lemak A, Wu B, Garcia M, Burnet MC, Meyer KM, Aryal UK, Sanchez O, Ansong C, Xiao R, Acton TB, Adkins JN, Montelione GT, Joachimiak A, Arrowsmith CH, Savchenko A, Szyperski T, Cort JR.

PLoS One. 2014 Jul 10;9(7):e101787. doi: 10.1371/journal.pone.0101787. eCollection 2014.


Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.

Gelato KA, Tauber M, Ong MS, Winter S, Hiragami-Hamada K, Sindlinger J, Lemak A, Bultsma Y, Houliston S, Schwarzer D, Divecha N, Arrowsmith CH, Fischle W.

Mol Cell. 2014 Jun 19;54(6):905-19. doi: 10.1016/j.molcel.2014.04.004. Epub 2014 May 8.


Basic Tilted Helix Bundle - a new protein fold in human FKBP25/FKBP3 and HectD1.

Helander S, Montecchio M, Lemak A, Farès C, Almlöf J, Yi Y, Yee A, Arrowsmith C, DhePaganon S, Sunnerhagen M.

Biochem Biophys Res Commun. 2014 Apr 25;447(1):26-31. doi: 10.1016/j.bbrc.2014.03.068. Epub 2014 Mar 22.


Solution NMR structure and histone binding of the PHD domain of human MLL5.

Lemak A, Yee A, Wu H, Yap D, Zeng H, Dombrovski L, Houliston S, Aparicio S, Arrowsmith CH.

PLoS One. 2013 Oct 9;8(10):e77020. doi: 10.1371/journal.pone.0077020. eCollection 2013.


Solution NMR structure, backbone dynamics, and heme-binding properties of a novel cytochrome c maturation protein CcmE from Desulfovibrio vulgaris.

Aramini JM, Hamilton K, Rossi P, Ertekin A, Lee HW, Lemak A, Wang H, Xiao R, Acton TB, Everett JK, Montelione GT.

Biochemistry. 2012 May 8;51(18):3705-7. doi: 10.1021/bi300457b. Epub 2012 Apr 24.


Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding.

Andresen C, Helander S, Lemak A, Farès C, Csizmok V, Carlsson J, Penn LZ, Forman-Kay JD, Arrowsmith CH, Lundström P, Sunnerhagen M.

Nucleic Acids Res. 2012 Jul;40(13):6353-66. Epub 2012 Mar 28.


Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A.

Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH.

J Biomol NMR. 2011 Sep;51(1-2):185-90. doi: 10.1007/s10858-011-9552-y. Epub 2011 Sep 27.


Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.

Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chédin F, Arrowsmith CH, Dhe-Paganon S.

J Biol Chem. 2011 Jul 8;286(27):24300-11. doi: 10.1074/jbc.M111.234104. Epub 2011 Apr 13.


A novel strategy for NMR resonance assignment and protein structure determination.

Lemak A, Gutmanas A, Chitayat S, Karra M, Farès C, Sunnerhagen M, Arrowsmith CH.

J Biomol NMR. 2011 Jan;49(1):27-38. doi: 10.1007/s10858-010-9458-0. Epub 2010 Dec 14.


Recognition and specificity determinants of the human cbx chromodomains.

Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, Wasney GA, Li Z, Vedadi M, Schapira M, Min J, Arrowsmith CH.

J Biol Chem. 2011 Jan 7;286(1):521-9. doi: 10.1074/jbc.M110.191411. Epub 2010 Nov 3.


NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases.

Wu B, Skarina T, Yee A, Jobin MC, Dileo R, Semesi A, Fares C, Lemak A, Coombes BK, Arrowsmith CH, Singer AU, Savchenko A.

PLoS Pathog. 2010 Jun 24;6(6):e1000960. doi: 10.1371/journal.ppat.1000960.


Simultaneous prediction of protein folding and docking at high resolution.

Das R, André I, Shen Y, Wu Y, Lemak A, Bansal S, Arrowsmith CH, Szyperski T, Baker D.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):18978-83. doi: 10.1073/pnas.0904407106. Epub 2009 Oct 28.


Molecular basis of Pirh2-mediated p53 ubiquitylation.

Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH.

Nat Struct Mol Biol. 2008 Dec;15(12):1334-42. doi: 10.1038/nsmb.1521. Epub 2008 Nov 30.


Sequence specific resonance assignment via Multicanonical Monte Carlo search using an ABACUS approach.

Lemak A, Steren CA, Arrowsmith CH, Llinás M.

J Biomol NMR. 2008 May;41(1):29-41. doi: 10.1007/s10858-008-9238-2. Epub 2008 May 6.


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