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Items: 1 to 20 of 45


Aristolochic acid I determine the phenotype and activation of macrophages in acute and chronic kidney disease.

Honarpisheh M, Foresto-Neto O, Steiger S, Kraft F, Koehler P, von Rauchhaupt E, Potempa J, Adamowicz K, Koziel J, Lech M.

Sci Rep. 2018 Aug 15;8(1):12169. doi: 10.1038/s41598-018-30628-x.


The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis.

Honarpisheh M, Köhler P, von Rauchhaupt E, Lech M.

J Immunol Res. 2018 May 8;2018:4126106. doi: 10.1155/2018/4126106. eCollection 2018. Review.


Anti-Transforming Growth Factor β IgG Elicits a Dual Effect on Calcium Oxalate Crystallization and Progressive Nephrocalcinosis-Related Chronic Kidney Disease.

Steiger S, Grill JF, Ma Q, Bäuerle T, Jordan J, Smolle M, Böhland C, Lech M, Anders HJ.

Front Immunol. 2018 Mar 29;9:619. doi: 10.3389/fimmu.2018.00619. eCollection 2018.


Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury.

Weidenbusch M, Rodler S, Song S, Romoli S, Marschner JA, Kraft F, Holderied A, Kumar S, Mulay SR, Honarpisheh M, Kumar Devarapu S, Lech M, Anders HJ.

Biosci Rep. 2017 Dec 22;37(6). pii: BSR20170099. doi: 10.1042/BSR20170099. Print 2017 Dec 22.


Worsening calcification propensity precedes all-cause and cardiovascular mortality in haemodialyzed patients.

Lorenz G, Steubl D, Kemmner S, Pasch A, Koch-Sembdner W, Pham D, Haller B, Bachmann Q, Mayer CC, Wassertheurer S, Angermann S, Lech M, Moog P, Bauer A, Heemann U, Schmaderer C.

Sci Rep. 2017 Oct 17;7(1):13368. doi: 10.1038/s41598-017-12859-6.


Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis.

Steiger S, Kumar SV, Honarpisheh M, Lorenz G, Günthner R, Romoli S, Gröbmayr R, Susanti HE, Potempa J, Koziel J, Lech M.

J Immunol. 2017 Aug 15;199(4):1440-1452. doi: 10.4049/jimmunol.1601982. Epub 2017 Jul 12.


Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner.

Glowczyk I, Wong A, Potempa B, Babyak O, Lech M, Lamont RJ, Potempa J, Koziel J.

Front Cell Infect Microbiol. 2017 Apr 27;7:140. doi: 10.3389/fcimb.2017.00140. eCollection 2017.


Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.

Honarpisheh M, Desai J, Marschner JA, Weidenbusch M, Lech M, Vielhauer V, Anders HJ, Mulay SR.

Biosci Rep. 2016 Dec 9;36(6). pii: e00425. doi: 10.1042/BSR20160336. Print 2016 Dec.


MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.

Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J.

J Innate Immun. 2016;8(6):564-578. Epub 2016 Aug 12.


Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.

Mulay SR, Eberhard JN, Desai J, Marschner JA, Kumar SV, Weidenbusch M, Grigorescu M, Lech M, Eltrich N, Müller L, Hans W, Hrabě de Angelis M, Vielhauer V, Hoppe B, Asplin J, Burzlaff N, Herrmann M, Evan A, Anders HJ.

J Am Soc Nephrol. 2017 Mar;28(3):761-768. doi: 10.1681/ASN.2016040486. Epub 2016 Sep 9.


Toll-like receptor activation in the pathogenesis of lupus nephritis.

Lorenz G, Lech M, Anders HJ.

Clin Immunol. 2017 Dec;185:86-94. doi: 10.1016/j.clim.2016.07.015. Epub 2016 Jul 14. Review.


How Kidney Cell Death Induces Renal Necroinflammation.

Mulay SR, Kumar SV, Lech M, Desai J, Anders HJ.

Semin Nephrol. 2016 May;36(3):162-73. doi: 10.1016/j.semnephrol.2016.03.004. Review.


The lymphotoxin β receptor is a potential therapeutic target in renal inflammation.

Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S.

Kidney Int. 2016 Jan;89(1):113-26. doi: 10.1038/ki.2015.280. Epub 2016 Jan 4.


Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.

Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V.

Nat Immunol. 2014 Nov;15(11):1079-89. doi: 10.1038/ni.3008. Epub 2014 Oct 5.


NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling.

Lech M, Lorenz G, Kulkarni OP, Grosser MO, Stigrot N, Darisipudi MN, Günthner R, Wintergerst MW, Anz D, Susanti HE, Anders HJ.

Ann Rheum Dis. 2015 Dec;74(12):2224-35. doi: 10.1136/annrheumdis-2014-205496. Epub 2014 Aug 18.


Expression profiling by real-time quantitative polymerase chain reaction (RT-qPCR).

Lech M, Anders HJ.

Methods Mol Biol. 2014;1169:133-42. doi: 10.1007/978-1-4939-0882-0_13.


Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.

Neumann K, Castiñeiras-Vilariño M, Höckendorf U, Hannesschläger N, Lemeer S, Kupka D, Meyermann S, Lech M, Anders HJ, Kuster B, Busch DH, Gewies A, Naumann R, Groß O, Ruland J.

Immunity. 2014 Mar 20;40(3):389-99. doi: 10.1016/j.immuni.2013.12.015. Epub 2014 Mar 13.


Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy.

Lech M, Gröbmayr R, Ryu M, Lorenz G, Hartter I, Mulay SR, Susanti HE, Kobayashi KS, Flavell RA, Anders HJ.

J Am Soc Nephrol. 2014 Feb;25(2):292-304. doi: 10.1681/ASN.2013020152. Epub 2013 Dec 5.


Pattern-recognition receptor signaling regulator mRNA expression in humans and mice, and in transient inflammation or progressive fibrosis.

Günthner R, Kumar VR, Lorenz G, Anders HJ, Lech M.

Int J Mol Sci. 2013 Sep 4;14(9):18124-47. doi: 10.3390/ijms140918124.


The pathogenesis of lupus nephritis.

Lech M, Anders HJ.

J Am Soc Nephrol. 2013 Sep;24(9):1357-66. doi: 10.1681/ASN.2013010026. Epub 2013 Aug 8. Review.

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