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Items: 8


The many disguises of the signalling endosome.

Villarroel-Campos D, Schiavo G, Lazo OM.

FEBS Lett. 2018 Sep 3. doi: 10.1002/1873-3468.13235. [Epub ahead of print] Review.


Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats.

Zepeda R, Contreras V, Pissani C, Stack K, Vargas M, Owen GI, Lazo OM, Bronfman FC.

Neuropharmacology. 2016 Aug;107:131-145. doi: 10.1016/j.neuropharm.2016.03.011. Epub 2016 Mar 8.


Spatiotemporal intracellular dynamics of neurotrophin and its receptors. Implications for neurotrophin signaling and neuronal function.

Bronfman FC, Lazo OM, Flores C, Escudero CA.

Handb Exp Pharmacol. 2014;220:33-65. doi: 10.1007/978-3-642-45106-5_3. Review.


The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release.

Escudero CA, Lazo OM, Galleguillos C, Parraguez JI, Lopez-Verrilli MA, Cabeza C, Leon L, Saeed U, Retamal C, Gonzalez A, Marzolo MP, Carter BD, Court FA, Bronfman FC.

J Cell Sci. 2014 May 1;127(Pt 9):1966-79. doi: 10.1242/jcs.141754. Epub 2014 Feb 25.


BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.

Lazo OM, Gonzalez A, AscaƱo M, Kuruvilla R, Couve A, Bronfman FC.

J Neurosci. 2013 Apr 3;33(14):6112-22. doi: 10.1523/JNEUROSCI.4630-12.2013.


Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.

Cabeza C, Figueroa A, Lazo OM, Galleguillos C, Pissani C, Klein A, Gonzalez-Billault C, Inestrosa NC, Alvarez AR, Zanlungo S, Bronfman FC.

Mol Neurodegener. 2012 Mar 29;7:11. doi: 10.1186/1750-1326-7-11.


Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons.

Lazo OM, Mauna JC, Pissani CA, Inestrosa NC, Bronfman FC.

Mol Neurodegener. 2010 Jan 19;5:5. doi: 10.1186/1750-1326-5-5.


An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors.

Guillemard V, Ivanisevic L, Garcia AG, Scholten V, Lazo OM, Bronfman FC, Saragovi HU.

Dev Neurobiol. 2010 Feb 15;70(3):150-64. doi: 10.1002/dneu.20776.

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