Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Nat Commun. 2017 May 24;8:15382. doi: 10.1038/ncomms15382.

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.

Author information

1
Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
2
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
3
Department of Computational Medicine &Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
4
23andMe, Inc., Mountain View, California 94041, USA.
5
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany.
6
St John's Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, UK.
7
Department of Medicine, Division of Rheumatology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
8
Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada M5T 2S8.
9
Department of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA.
10
Department of Dermatology, Linköping University, Linköping SE-581 83, Sweden.
11
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
12
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
13
Institute of Human Genetics, University of Bonn, Bonn 53127, Germany.
14
Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel 4031, Switzerland.
15
Dermatology Clinic, Tartu University Hospital, Department of Dermatology and Venereology, University of Tartu, Tartu 50417, Estonia.
16
Department of Pathophysiology, Centre of Translational Medicine and Centre for Translational Genomics, University of Tartu, Tartu 50411, Estonia.
17
Department of Reproductive Biology, Estonian University of Life Sciences, Tartu 51006, Estonia.
18
Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
19
Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
20
Memorial University, St. John's, Newfoundland, Newfoundland and Labrador, Canada A1B 3X9.
21
Institute of Human Genetics, FAU Erlangen-Nürnberg, Erlangen 91054, Germany.
22
Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan 48105, USA.
23
Department of Medical and Molecular Genetics, King's College London, London WC2R 2LS, UK.

Abstract

Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFκB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8+ T-cells and CD4+ T-cells including TH0, TH1 and TH17). The identified loci explain ∼28% of the genetic heritability and generate a discriminatory genetic risk score (AUC=0.76 in our sample) that is significantly correlated with age at onset (p=2 × 10-89). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis.

PMID:
28537254
PMCID:
PMC5458077
DOI:
10.1038/ncomms15382
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center