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PLoS One. 2017 Dec 13;12(12):e0189141. doi: 10.1371/journal.pone.0189141. eCollection 2017.

Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females-Double isotope sequential single-blind studies in menstruating women.

Author information

1
Department of Gastroenterology and Hepatology, Section for Clinical Nutrition, Sahlgrenska University Hospital, Gothenburg, Sweden.
2
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
3
Biomedical Nutrition, Pure and Applied Biochemistry, Center for Applied Life Sciences, Lund University, Lund, Sweden.
4
Probi AB, Ideon Gamma 1, Lund, Sweden.

Abstract

BACKGROUND:

The probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption.

OBJECTIVE:

The aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843).

STUDY DESIGN:

With a single blinded placebo controlled sequential design, iron absorption from a light breakfast meal administered with or without capsules containing 1010 cfu freeze-dried Lp299v was studied in healthy female volunteers of fertile age. The methodology used was a double isotope technique (59Fe and 55Fe). Two studies were performed using the same protocol.

RESULTS:

In study 1, the absorption of iron from a meal without Lp299v was found to be 17.4 ± 13.4%, and from an identical meal with Lp299v was found to be 22.4 ± 17.3% (mean ± SD). This difference was statistically significant (p = 0.040, n = 14). In study 2, the absorption of iron from a meal without Lp299v was found to be 20.9 ± 13.1%, and from an identical meal with Lp299v found to be 24.5 ± 12.0% (mean ± SD, n = 28), which again was statistically significant (p = 0.003).

CONCLUSION:

Freeze-dried Lp299v enhances the absorption of iron when administered together with a meal with a high iron bioavailability.

TRIAL REGISTRATION:

ClinicalTrials.gov Identifier: NCT02131870.

PMID:
29236734
PMCID:
PMC5728536
DOI:
10.1371/journal.pone.0189141
[Indexed for MEDLINE]
Free PMC Article

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