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Items: 1 to 20 of 28


In silico site-directed mutagenesis informs species-specific predictions of chemical susceptibility derived from the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool.

Doering JA, Lee S, Kristiansen K, Evenseth L, Barron MG, Sylte I, LaLone CA.

Toxicol Sci. 2018 Jul 27. doi: 10.1093/toxsci/kfy186. [Epub ahead of print]


Advancing the adverse outcome pathway framework-An international horizon scanning approach.

LaLone CA, Ankley GT, Belanger SE, Embry MR, Hodges G, Knapen D, Munn S, Perkins EJ, Rudd MA, Villeneuve DL, Whelan M, Willett C, Zhang X, Hecker M.

Environ Toxicol Chem. 2017 Jun;36(6):1411-1421. doi: 10.1002/etc.3805.


Derivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Female Fish.

Martinovic-Weigelt D, Mehinto AC, Ankley GT, Berninger JP, Collette TW, Davis JM, Denslow ND, Durhan EJ, Eid E, Ekman DR, Jensen KM, Kahl MD, LaLone CA, Teng Q, Villeneuve DL.

Toxicol Sci. 2017 Apr 1;156(2):344-361. doi: 10.1093/toxsci/kfw257.


Practical approaches to adverse outcome pathway development and weight-of-evidence evaluation as illustrated by ecotoxicological case studies.

Fay KA, Villeneuve DL, LaLone CA, Song Y, Tollefsen KE, Ankley GT.

Environ Toxicol Chem. 2017 Jun;36(6):1429-1449. doi: 10.1002/etc.3770. Epub 2017 Mar 31. Review.


Metabolomics for informing adverse outcome pathways: Androgen receptor activation and the pharmaceutical spironolactone.

Davis JM, Ekman DR, Skelton DM, LaLone CA, Ankley GT, Cavallin JE, Villeneuve DL, Collette TW.

Aquat Toxicol. 2017 Mar;184:103-115. doi: 10.1016/j.aquatox.2017.01.001. Epub 2017 Jan 16.


Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death.

LaLone CA, Villeneuve DL, Wu-Smart J, Milsk RY, Sappington K, Garber KV, Housenger J, Ankley GT.

Sci Total Environ. 2017 Apr 15;584-585:751-775. doi: 10.1016/j.scitotenv.2017.01.113. Epub 2017 Jan 24. Review.


Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.

Tal T, Kilty C, Smith A, LaLone C, Kennedy B, Tennant A, McCollum CW, Bondesson M, Knudsen T, Padilla S, Kleinstreuer N.

Reprod Toxicol. 2017 Jun;70:70-81. doi: 10.1016/j.reprotox.2016.12.004. Epub 2016 Dec 19.


Evaluation of the scientific underpinnings for identifying estrogenic chemicals in nonmammalian taxa using mammalian test systems.

Ankley GT, LaLone CA, Gray LE, Villeneuve DL, Hornung MW.

Environ Toxicol Chem. 2016 Nov;35(11):2806-2816. doi: 10.1002/etc.3456. Epub 2016 Jun 28.


Editor's Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity.

LaLone CA, Villeneuve DL, Lyons D, Helgen HW, Robinson SL, Swintek JA, Saari TW, Ankley GT.

Toxicol Sci. 2016 Oct;153(2):228-45. doi: 10.1093/toxsci/kfw119. Epub 2016 Jun 30.


Evaluation of whole-mount in situ hybridization as a tool for pathway-based toxicological research with early-life stage fathead minnows.

Cavallin JE, Schroeder AL, Jensen KM, Villeneuve DL, Blackwell BR, Carlson K, Kahl MD, LaLone CA, Randolph EC, Ankley GT.

Aquat Toxicol. 2015 Dec;169:19-26. doi: 10.1016/j.aquatox.2015.10.002. Epub 2015 Oct 18.


Pathway-based approaches for assessment of real-time exposure to an estrogenic wastewater treatment plant effluent on fathead minnow reproduction.

Cavallin JE, Jensen KM, Kahl MD, Villeneuve DL, Lee KE, Schroeder AL, Mayasich J, Eid EP, Nelson KR, Milsk RY, Blackwell BR, Berninger JP, LaLone CA, Blanksma C, Jicha T, Elonen C, Johnson R, Ankley GT.

Environ Toxicol Chem. 2016 Mar;35(3):702-16. doi: 10.1002/etc.3228. Epub 2016 Feb 9.


Prioritization of pharmaceuticals for potential environmental hazard through leveraging a large-scale mammalian pharmacological dataset.

Berninger JP, LaLone CA, Villeneuve DL, Ankley GT.

Environ Toxicol Chem. 2016 Apr;35(4):1007-20. doi: 10.1002/etc.2965. Epub 2015 Jun 22.


Adverse outcome pathway development II: best practices.

Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M.

Toxicol Sci. 2014 Dec;142(2):321-30. doi: 10.1093/toxsci/kfu200.


Adverse outcome pathway (AOP) development I: strategies and principles.

Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M.

Toxicol Sci. 2014 Dec;142(2):312-20. doi: 10.1093/toxsci/kfu199.


Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms.

LaLone CA, Berninger JP, Villeneuve DL, Ankley GT.

Philos Trans R Soc Lond B Biol Sci. 2014 Nov 19;369(1656). pii: 20140022. doi: 10.1098/rstb.2014.0022. Review.


Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality.

Russom CL, LaLone CA, Villeneuve DL, Ankley GT.

Environ Toxicol Chem. 2014 Oct;33(10):2157-69. doi: 10.1002/etc.2662. Epub 2014 Aug 25. Review.


Integrated assessment of runoff from livestock farming operations: Analytical chemistry, in vitro bioassays, and in vivo fish exposures.

Cavallin JE, Durhan EJ, Evans N, Jensen KM, Kahl MD, Kolpin DW, Kolodziej EP, Foreman WT, LaLone CA, Makynen EA, Seidl SM, Thomas LM, Villeneuve DL, Weberg MA, Wilson VS, Ankley GT.

Environ Toxicol Chem. 2014 Aug;33(8):1849-57. doi: 10.1002/etc.2627. Epub 2014 Jun 27. Erratum in: Environ Toxicol Chem. 2014 Nov;33(11):2646.


An inexpensive, temporally integrated system for monitoring occurrence and biological effects of aquatic contaminants in the field.

Kahl MD, Villeneuve DL, Stevens K, Schroeder A, Makynen EA, LaLone CA, Jensen KM, Hughes M, Holmen BA, Eid E, Durhan EJ, Cavallin JE, Berninger J, Ankley GT.

Environ Toxicol Chem. 2014 Jul;33(7):1584-95. doi: 10.1002/etc.2591. Epub 2014 May 20.


Molecular target sequence similarity as a basis for species extrapolation to assess the ecological risk of chemicals with known modes of action.

Lalone CA, Villeneuve DL, Burgoon LD, Russom CL, Helgen HW, Berninger JP, Tietge JE, Severson MN, Cavallin JE, Ankley GT.

Aquat Toxicol. 2013 Nov 15;144-145:141-54. doi: 10.1016/j.aquatox.2013.09.004. Epub 2013 Sep 19.


Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone.

LaLone CA, Villeneuve DL, Cavallin JE, Kahl MD, Durhan EJ, Makynen EA, Jensen KM, Stevens KE, Severson MN, Blanksma CA, Flynn KM, Hartig PC, Woodard JS, Berninger JP, Norberg-King TJ, Johnson RD, Ankley GT.

Environ Toxicol Chem. 2013 Nov;32(11):2528-41. doi: 10.1002/etc.2330. Epub 2013 Sep 6.


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