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J Cyst Fibros. 2016 May;15(3):400-5. doi: 10.1016/j.jcf.2015.12.010. Epub 2016 Jan 6.

Low sodium status in cystic fibrosis-as assessed by calculating fractional Na(+) excretion-is associated with decreased growth parameters.

Author information

  • 1Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
  • 2Department of Pediatrics III, Cystic Fibrosis Center, Medical University of Innsbruck, Innsbruck, Austria.
  • 3Department of General and Transplant Surgery, Division of Pediatric Surgery, Medical University of Innsbruck, Innsbruck, Austria.
  • 4Division of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria.
  • 5Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: peter.heinz-erian@tirol-kliniken.at.

Abstract

BACKGROUND:

In CF infants, normonatremic Na(+) depletion (NNaD), identified by fractional Na(+) excretion (FENa) values <0.5%, was recently linked to impaired growth. Our paper investigates the relationship between FENa and growth in CF children >2years.

METHODS:

FENa values were calculated in 35 CF and 24 control children, and tested for correlations with z-scores for weight, height and BMI.

RESULTS:

All CF children and controls had normal plasma Na(+) concentrations. A total of 25 of 35 (71.4%) CF patients had decreased FENa values <0.5% (group I). FENa results of 10 CF patients (group II) and 23/24 controls (group III) were normal. In Na(+)-depleted CF children, compared to normal controls, mean z-scores for weight (-0.18±0.87 vs +1.03±0.57, p<0.001), height (-0.06±0.89 vs +0.53±0.72, p=0.009) and BMI (-0.22±0.87 vs +1.00±1.06, p<0.001) were significantly reduced. Also, we found positive correlations between FENa values and z-scores for weight (r=0.521), height (r=0.292) and BMI (r=0.468), respectively.

CONCLUSION:

NNaD may contribute to poor growth in CF.

KEYWORDS:

Cystic fibrosis; Fractional sodium excretion; Growth retardation; Normonatremic sodium depletion

PMID:
26777601
DOI:
10.1016/j.jcf.2015.12.010
[PubMed - in process]
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