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Page 1
LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features.
Villalonga E, Mosrin C, Normand T, Girardin C, Serrano A, Žunar B, Doudeau M, Godin F, Bénédetti H, Vallée B. Villalonga E, et al. Cells. 2023 Mar 4;12(5):805. doi: 10.3390/cells12050805. Cells. 2023. PMID: 36899941 Free PMC article. Review.
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase family. ...Consequently, they are also part of numerous pathological mechanisms, especially in cancer, where their involvement has been report …
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases and the only two members of the LIM kinase fa …
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y. Chen L, et al. Cancer Lett. 2023 Nov 1;576:216420. doi: 10.1016/j.canlet.2023.216420. Epub 2023 Sep 29. Cancer Lett. 2023. PMID: 37778684
However, whether elevated expression of LIMK1 leads to chemoresistance due to m(6)A modification remains to be further studied. ...Moreover, downregulation of YTH domain-containing 2 (YTHDC2), an m(6)A "reader", in CRC cells resulted in decreased recognition and binding to …
However, whether elevated expression of LIMK1 leads to chemoresistance due to m(6)A modification remains to be further studied. ...Mo …
LIMK1: A promising prognostic and immune infiltration indicator in colorectal cancer.
Liu X, Song Q, Wang D, Liu Y, Zhang Z, Fu W. Liu X, et al. Oncol Lett. 2022 May 30;24(1):234. doi: 10.3892/ol.2022.13354. eCollection 2022 Jul. Oncol Lett. 2022. PMID: 35720504 Free PMC article.
STRING was used to analyze co-expression genes of LIMK1. The tumor immune estimation resource was applied to the correlation between LIMK1 expression and immune infiltrates. ...The AUC value of LIMK1 in CRC was 0.937 (95% CI: 0.918-0.957) through ROC analysis …
STRING was used to analyze co-expression genes of LIMK1. The tumor immune estimation resource was applied to the correlation between …
LIMK1 depletion enhances fasudil-dependent inhibition of urethral fibroblast proliferation and migration.
Liang YC, Li XD, Wu YP, Ke ZB, Liu ZQ, Chen SH, Wei Y, Zheng QS, Xue XY, Xu N. Liang YC, et al. J Cell Biochem. 2019 Aug;120(8):12977-12988. doi: 10.1002/jcb.28569. Epub 2019 Mar 12. J Cell Biochem. 2019. PMID: 30861189

In vitro cultures of urethral fibroblasts were divided into LIMK1 knockdown (LIMK1 KD) and LIMK1 control (LIMK1 NC) experimental groups. ...Cell migration was also attenuated in the LIMK1 KD group treated with fasudil ( P < 0.05). Flow cytome

…
In vitro cultures of urethral fibroblasts were divided into LIMK1 knockdown (LIMK1 KD) and LIMK1 control (LIMK1 …
Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture.
Zhou F, Ouyang L, Li Q, Yang S, Liu S, Yu H, Jia Q, Rao S, Xie J, Du G, Feng C, Fan G. Zhou F, et al. Mol Neurobiol. 2023 Oct;60(10):6029-6042. doi: 10.1007/s12035-023-03458-w. Epub 2023 Jul 6. Mol Neurobiol. 2023. PMID: 37407880
Hence, we investigated the role of LIMK1 activity in low-dose heavy metal mixture-induced neurobehavioral deficits and structural synaptic plasticity disorders. ...The potent LIMK1 inhibitor BMS-5 yielded similar results induced by heavy metal mixture exposure and a …
Hence, we investigated the role of LIMK1 activity in low-dose heavy metal mixture-induced neurobehavioral deficits and structural syn …
circ-LIMK1 regulates cisplatin resistance in lung adenocarcinoma by targeting miR-512-5p/HMGA1 axis.
Li Y, Li F, Wang Y, Song F, Qi L, Hu Q. Li Y, et al. Open Med (Wars). 2022 Oct 7;17(1):1568-1583. doi: 10.1515/med-2022-0542. eCollection 2022. Open Med (Wars). 2022. PMID: 36304135 Free PMC article.
Knockdown of circ-LIMK1 reduced DDP resistance, impaired cancer cell growth, migration, invasion, and angiogenesis. circ-LIMK1 targeted miR-512-5p, and HMGA1 was targeted by miR-512-5p. ...Knockdown of circ-LIMK1 could reduce growth of DDP-resistant tumors in …
Knockdown of circ-LIMK1 reduced DDP resistance, impaired cancer cell growth, migration, invasion, and angiogenesis. circ-LIMK1 …
LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target.
Kang X, Li W, Liu W, Liang H, Deng J, Wong CC, Zhao S, Kang W, To KF, Chiu PWY, Wang G, Yu J, Ng EKW. Kang X, et al. Oncogene. 2021 May;40(19):3422-3433. doi: 10.1038/s41388-021-01656-1. Epub 2021 Apr 21. Oncogene. 2021. PMID: 33883692 Free PMC article.
LIMK1 knockout also abrogated peritoneal and liver metastases of gastric cancer cells in nude mice in vivo. ...Mechanistically, either LIMK1 knockout or Dabrafenib inhibited LIMK1 expression and phosphorylation of its downstream target cofilin. ...
LIMK1 knockout also abrogated peritoneal and liver metastases of gastric cancer cells in nude mice in vivo. ...Mechanistically, eithe …
LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome.
Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI. Hoogenraad CC, et al. Bioessays. 2004 Feb;26(2):141-50. doi: 10.1002/bies.10402. Bioessays. 2004. PMID: 14745832 Review.
Two of these genes encode proteins that regulate dynamic aspects of the cytoskeleton of the cell, either via the actin filament system (LIM kinase 1, or LIMK1), or through the microtubule network (cytoplasmic linker protein of 115 kDa, or CLIP-115). The recent findings tha …
Two of these genes encode proteins that regulate dynamic aspects of the cytoskeleton of the cell, either via the actin filament system (LIM …
LIMK1 Interacts with STK25 to Regulate EMT and Promote the Proliferation and Metastasis of Colorectal Cancer.
Sun X, Li S, Lin H. Sun X, et al. J Oncol. 2022 Feb 28;2022:3963883. doi: 10.1155/2022/3963883. eCollection 2022. J Oncol. 2022. PMID: 35265128 Free PMC article.
The overexpression plasmids of LIMK1 and STK25 were constructed. An shRNA specific to LIMK1 was synthesized and transfected into colon cancer cell lines. ...RESULTS: LIMK1 interacted with STK25 and was highly expressed in colon cancer. ...
The overexpression plasmids of LIMK1 and STK25 were constructed. An shRNA specific to LIMK1 was synthesized and transfected in …
FOXD3-AS1/miR-128-3p/LIMK1 axis regulates cervical cancer progression.
Yang X, Du H, Bian W, Li Q, Sun H. Yang X, et al. Oncol Rep. 2021 May;45(5):62. doi: 10.3892/or.2021.8013. Epub 2021 Mar 24. Oncol Rep. 2021. PMID: 33760158 Free PMC article.
Reverse transcription-quantitative PCR was performed to detect FOXD3-AS1, microRNA (miR)-128-3p and LIM domain kinase 1 (LIMK1) expression levels in CC tissues and cells. Immunohistochemical staining and western blotting were conducted to assess LIMK1 protein expres …
Reverse transcription-quantitative PCR was performed to detect FOXD3-AS1, microRNA (miR)-128-3p and LIM domain kinase 1 (LIMK1) expre …
770 results