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138 results

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Page 1
LHX9, a p53-binding protein, inhibits the progression of glioma by suppressing glycolysis.
Luo X, Ge J, Chen T, Liu J, Liu Z, Bi C, Lan S. Luo X, et al. Aging (Albany NY). 2021 Sep 17;13(18):22109-22119. doi: 10.18632/aging.203436. Epub 2021 Sep 17. Aging (Albany NY). 2021. PMID: 34536269 Free PMC article.
In addition, the interaction between LHX9 and P53 was analyzed by immunoprecipitation, and the roles of LHX9 in cancer metabolism were explored by measuring metabolites. ...Regarding the molecular mechanism, we found that LHX9 interacted with p53, and downreg …
In addition, the interaction between LHX9 and P53 was analyzed by immunoprecipitation, and the roles of LHX9 in cancer metabol …
Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression.
Zhao H, Jiang R, Feng Z, Wang X, Zhang C. Zhao H, et al. J Transl Med. 2023 Nov 18;21(1):833. doi: 10.1186/s12967-023-04658-7. J Transl Med. 2023. PMID: 37980488 Free PMC article.
High LHX9 expression could be used as a reference marker for prognosis prediction of GC patients. ...CONCLUSION: The findings suggest that both LHX9 and PKM2 are highly expressed in GCs, and LHX9 may induce the reprogramming of glycolytic metabolism through t …
High LHX9 expression could be used as a reference marker for prognosis prediction of GC patients. ...CONCLUSION: The findings suggest …
Increased LHX9 expression in alveolar epithelial type 2 cells of patients with chronic obstructive pulmonary disease.
Okutomo K, Fujino N, Yamada M, Saito T, Ono Y, Okada Y, Ichinose M, Sugiura H. Okutomo K, et al. Respir Investig. 2022 Jan;60(1):119-128. doi: 10.1016/j.resinv.2021.08.007. Epub 2021 Sep 20. Respir Investig. 2022. PMID: 34548271
The airflow obstruction was independently correlated with the increase in LHX9 expression. Among several pro-inflammatory cytokines, interferon-gamma was a strong inducer of LHX9 expression in A549 cells. ...Considering the independent association of the increased …
The airflow obstruction was independently correlated with the increase in LHX9 expression. Among several pro-inflammatory cytokines, …
The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus.
Yamazaki F, Møller M, Fu C, Clokie SJ, Zykovich A, Coon SL, Klein DC, Rath MF. Yamazaki F, et al. Brain Struct Funct. 2015;220(3):1497-509. doi: 10.1007/s00429-014-0740-x. Epub 2014 Mar 20. Brain Struct Funct. 2015. PMID: 24647753 Free PMC article.
Deletion of Lhx9 results in sterility due to failure of gonadal development. ...The deep pineal gland and the pineal stalk are also reduced in size. Although the brains of neonatal Lhx9(-/-) mutant mice appear normal, severe hydrocephalus develops in about 70% of th …
Deletion of Lhx9 results in sterility due to failure of gonadal development. ...The deep pineal gland and the pineal stalk are also r …
Lhx9 Is Required for the Development of Retinal Nitric Oxide-Synthesizing Amacrine Cell Subtype.
Balasubramanian R, Bui A, Dong X, Gan L. Balasubramanian R, et al. Mol Neurobiol. 2018 Apr;55(4):2922-2933. doi: 10.1007/s12035-017-0554-y. Epub 2017 Apr 29. Mol Neurobiol. 2018. PMID: 28456934 Free PMC article.
One such amacrine cell subtype comprises neuronal nitric oxide synthase (nNOS/bNOS/NOS1)-expressing amacrine cells (NOACs) that regulate the release of nitric oxide (NO), a neurotransmitter with physiological and clinical implications in the retina. We have identified the LIM-hom …
One such amacrine cell subtype comprises neuronal nitric oxide synthase (nNOS/bNOS/NOS1)-expressing amacrine cells (NOACs) that regulate the …
Lhx9 gene expression during early limb development in mice requires the FGF signalling pathway.
Yang Y, Wilson MJ. Yang Y, et al. Gene Expr Patterns. 2015 Sep-Nov;19(1-2):45-51. doi: 10.1016/j.gep.2015.07.002. Epub 2015 Jul 26. Gene Expr Patterns. 2015. PMID: 26220830
Three splice variants of the Lhx9 transcript are expressed during development, two of which are predicted to act in a dominant negative fashion, competing with the DNA binding version of Lhx9 for binding to cofactors via the LIM-domain. ...Additionally we determined …
Three splice variants of the Lhx9 transcript are expressed during development, two of which are predicted to act in a dominant negati …
Generation and characterization of Lhx9-GFPCreER(T2) knock-in mouse line.
Balasubramanian R, Bui A, Xie X, Deng M, Gan L. Balasubramanian R, et al. Genesis. 2014 Sep;52(9):827-832. doi: 10.1002/dvg.22805. Epub 2014 Aug 12. Genesis. 2014. PMID: 25112520 Free PMC article.
We recently reported the expression of LHX9 in retinal amacrine cells during development. In this study, we generated an Lhx9-GFPCreER(T) (2) (GCE) knock-in mouse line by knocking-in a GCE cassette at the Lhx9 locus, thus inactivating endogenous Lhx9. …
We recently reported the expression of LHX9 in retinal amacrine cells during development. In this study, we generated an Lhx9- …
Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation.
Mollé B, Père S, Failli V, Bach I, Rétaux S. Mollé B, et al. DNA Cell Biol. 2004 Nov;23(11):761-8. doi: 10.1089/dna.2004.23.761. DNA Cell Biol. 2004. PMID: 15585134
The Lhx9 LIM-homeodomain transcription factor and its truncated isoform Lhx9alpha are generated by alternative splicing of the Lhx9 gene. ...Thus, Lhx9 and Lhx9alpha isoforms could be implicated in regulating various aspects of neuronal differentiation....
The Lhx9 LIM-homeodomain transcription factor and its truncated isoform Lhx9alpha are generated by alternative splicing of the Lhx …
FGF-induced LHX9 regulates the progression and metastasis of osteosarcoma via FRS2/TGF-beta/beta-catenin pathway.
Li SQ, Tu C, Wan L, Chen RQ, Duan ZX, Ren XL, Li ZH. Li SQ, et al. Cell Div. 2019 Nov 25;14:13. doi: 10.1186/s13008-019-0056-6. eCollection 2019. Cell Div. 2019. PMID: 31788020 Free PMC article.
Knockdown of LHX9 impaired the proliferation, migration, invasion and metastasis of OS cells. ...By contrast, FRS2 knockdown conduced to the up-regulation of LHX9, BMP4, beta-catenin and TGF-betaR1, while TGF-beta inhibition repressed the expression of LHX9 a …
Knockdown of LHX9 impaired the proliferation, migration, invasion and metastasis of OS cells. ...By contrast, FRS2 knockdown conduced …
The Lhx9-integrin pathway is essential for positioning of the proepicardial organ.
Tandon P, Wilczewski CM, Williams CE, Conlon FL. Tandon P, et al. Development. 2016 Mar 1;143(5):831-40. doi: 10.1242/dev.129551. Epub 2016 Jan 25. Development. 2016. PMID: 26811386 Free PMC article.
Utilizing a small-molecule screen, we found that Lhx9 acts upstream of integrin-paxillin signaling and consistently demonstrate that either loss of Lhx9 or disruption of the integrin-paxillin pathway results in mis-positioning of the proepicardial organ and aberrant …
Utilizing a small-molecule screen, we found that Lhx9 acts upstream of integrin-paxillin signaling and consistently demonstrate that …
138 results