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Roles of Lamtor1 in Macrophages, CD4+ T-cells, and Regulatory T-cells.
Kimura T, Kumanogoh A, Okada M. Kimura T, et al. Crit Rev Immunol. 2018;38(5):403-414. doi: 10.1615/CritRevImmunol.2018028252. Crit Rev Immunol. 2018. PMID: 30806216 Review.
Lamtor1 is a lysosome-anchored protein that was first reported in 2009. In this review, we describe the discovery and intracellular functions of Lamtor1, as well as physiological roles of Lamtor1 in immune cells, namely, macrophages, CD4+ helper T-cells, and …
Lamtor1 is a lysosome-anchored protein that was first reported in 2009. In this review, we describe the discovery and intracellular f …
USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.
Hertel A, Alves LM, Dutz H, Tascher G, Bonn F, Kaulich M, Dikic I, Eimer S, Steinberg F, Bremm A. Hertel A, et al. Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653. Cell Rep. 2022. PMID: 36476874 Free article.
Knockout (KO) of USP32 in primary hTERT-RPE1 cells results among others in hyperubiquitination of the Ragulator complex subunit LAMTOR1. Accumulation of LAMTOR1 ubiquitination impairs its interaction with the vacuolar H(+)-ATPase, reduces Ragulator function, and ult …
Knockout (KO) of USP32 in primary hTERT-RPE1 cells results among others in hyperubiquitination of the Ragulator complex subunit LAMTOR1 …
LAMTOR1 ubiquitination restricts its interaction with the vacuolar-type H(+)-ATPase, promotes autophagy and is controlled by USP32.
Hertel A, Eimer S, Bremm A. Hertel A, et al. Autophagy. 2023 Aug;19(8):2406-2407. doi: 10.1080/15548627.2023.2184958. Epub 2023 Mar 1. Autophagy. 2023. PMID: 36847417 Free PMC article.
Recently, we identified a non-proteolytic ubiquitin signal at the Ragulator complex subunit LAMTOR1 that is reversed by the deubiquitinase USP32. Loss of USP32 promotes ubiquitination within the unstructured N-terminal region of LAMTOR1 and prevents its efficient in …
Recently, we identified a non-proteolytic ubiquitin signal at the Ragulator complex subunit LAMTOR1 that is reversed by the deubiquit …
LAMTOR1 degrades MHC-II via the endocytic in hepatocellular carcinoma.
Wu B, Wang Q, Li B, Jiang M. Wu B, et al. Carcinogenesis. 2022 Dec 25;43(11):1059-1070. doi: 10.1093/carcin/bgac075. Carcinogenesis. 2022. PMID: 36070764 Free PMC article.
Therefore, the regulation of the endocytosis pathway on the expression of MHC-II surface level and antitumor T cell response remains to be explored. In this experiment, we found that LAMTOR1 regulates the endocytic pathway through the GTPase domain of DNM2 and triggers the …
Therefore, the regulation of the endocytosis pathway on the expression of MHC-II surface level and antitumor T cell response remains to be e …
LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function.
Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, Baudry M, Bi X. Sun J, et al. EMBO J. 2022 Mar 1;41(5):e108119. doi: 10.15252/embj.2021108119. Epub 2022 Jan 31. EMBO J. 2022. PMID: 35099830 Free PMC article.
LAMTOR1 directly interacts with TRPML1 through its N-terminal domain. Eliminating this inhibition in hippocampal neurons by LAMTOR1 deletion or by disrupting LAMTOR1-TRPML1 binding increases TRPML1-mediated Ca(2+) release and facilitates dendritic lysosomal t …
LAMTOR1 directly interacts with TRPML1 through its N-terminal domain. Eliminating this inhibition in hippocampal neurons by LAMTOR …
LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy.
Lin CY, Nozawa T, Minowa-Nozawa A, Toh H, Aikawa C, Nakagawa I. Lin CY, et al. Cell Microbiol. 2019 Apr;21(4):e12981. doi: 10.1111/cmi.12981. Epub 2019 Jan 21. Cell Microbiol. 2019. PMID: 30428163
LAMTOR1 was localized to bacterium-containing endosomes, and LAMTOR2 was recruited to bacterium-containing damaged endosomes in a LAMTOR1-dependent manner. ...Notably, knockout of TAX1BP1 caused a reduction in autolysosome formation and subsequent bacterial degradat …
LAMTOR1 was localized to bacterium-containing endosomes, and LAMTOR2 was recruited to bacterium-containing damaged endosomes in a …
The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Tsujimoto K, Jo T, Nagira D, Konaka H, Park JH, Yoshimura SI, Ninomiya A, Sugihara F, Hirayama T, Itotagawa E, Matsuzaki Y, Takaichi Y, Aoki W, Saita S, Nakamura S, Ballabio A, Nada S, Okada M, Takamatsu H, Kumanogoh A. Tsujimoto K, et al. EMBO J. 2023 Jan 4;42(1):e111389. doi: 10.15252/embj.2022111389. Epub 2022 Nov 29. EMBO J. 2023. PMID: 36444797 Free PMC article.
Mechanistically, Lamtor1 interacted with both NLRP3 and histone deacetylase 6 (HDAC6). HDAC6 enhances the interaction between Lamtor1 and NLRP3, resulting in NLRP3 inflammasome activation. DL-all-rac-alpha-tocopherol, a synthetic form of vitamin E, inhibited the …
Mechanistically, Lamtor1 interacted with both NLRP3 and histone deacetylase 6 (HDAC6). HDAC6 enhances the interaction between Lamt …
Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.
Ying L, Zhang M, Ma X, Si Y, Li X, Su J, Yin J, Bao Y. Ying L, et al. Front Cell Dev Biol. 2021 May 20;9:672032. doi: 10.3389/fcell.2021.672032. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34095141 Free PMC article.
Here, we studied the metabolic function of LAMTOR1 from macrophages using LAMTOR1 macrophage-specific knockout (MKO) mice. ...Therefore, our results provide a new perspective for macrophage-derived LAMTOR1 in the context of systemic metabolism....
Here, we studied the metabolic function of LAMTOR1 from macrophages using LAMTOR1 macrophage-specific knockout (MKO) mice. ... …
TRAF4-Mediated LAMTOR1 Ubiquitination Promotes mTORC1 Activation and Inhibits the Inflammation-Induced Colorectal Cancer Progression.
Zhao L, Gao N, Peng X, Chen L, Meng T, Jiang C, Jin J, Zhang J, Duan Q, Tian H, Weng L, Wang X, Tan X, Li Y, Qin H, Yuan J, Ge X, Deng L, Wang P. Zhao L, et al. Adv Sci (Weinh). 2024 Mar;11(12):e2301164. doi: 10.1002/advs.202301164. Epub 2024 Jan 16. Adv Sci (Weinh). 2024. PMID: 38229144 Free PMC article.
It is found that the E3 ligase TRAF4 directly interacts with LAMTOR1 and catalyzes the K63-linked polyubiquitination of LAMTOR1 at K151. ...This study revealed that TRAF4-mediated LAMTOR1 ubiquitination is a regulatory mechanism for mTORC1 activation and prov …
It is found that the E3 ligase TRAF4 directly interacts with LAMTOR1 and catalyzes the K63-linked polyubiquitination of LAMTOR1 …
Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts.
Liu JT, Yao QP, Chen Y, Lv F, Liu Z, Bao H, Han Y, Zhang ML, Jiang ZL, Qi YX. Liu JT, et al. Theranostics. 2022 Jun 21;12(11):4851-4865. doi: 10.7150/thno.69551. eCollection 2022. Theranostics. 2022. PMID: 35836818 Free PMC article.
Arterial mechanical stretch (10% elongation) induced circSlc8a1 expression and positively regulated Lamtor1, activated mTORC1 and promoted SMC dedifferentiation and proliferation. Local injection of circSlc8a1 siRNA or SMC-specific Lamtor1 knockout mice prevented ne …
Arterial mechanical stretch (10% elongation) induced circSlc8a1 expression and positively regulated Lamtor1, activated mTORC1 and pro …
85 results