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Lung Cancer. 2015 Nov;90(2):334-41. doi: 10.1016/j.lungcan.2015.07.012. Epub 2015 Jul 30.

Humoral immune responses of lung cancer patients against the Transmembrane Phosphatase with TEnsin homology (TPTE).

Author information

1
Department of Hematology, Medical Oncology & Pneumology, University Medical Center Mainz, 55131 Mainz, Germany. Electronic address: andreas.kuemmel@unimedizin-mainz.de.
2
Department of Hematology, Medical Oncology & Pneumology, University Medical Center Mainz, 55131 Mainz, Germany; TRON gGmbH, Translational Oncology at the University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.
3
Department of Hematology, Medical Oncology & Pneumology, University Medical Center Mainz, 55131 Mainz, Germany.
4
Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg-University, 55101 Mainz, Germany.
5
Department of Medicine A, University Medical Center Muenster, 48149 Muenster, Germany.
6
Department of Medicine III, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany.
7
Ganymed Pharmaceuticals AG, Freiligrathstr.12, 55131 Mainz, Germany.

Abstract

OBJECTIVE:

The cancer/testis (C/T) antigen Transmembrane Phosphatase with TEnsin homology (TPTE) is aberrantly expressed in many tumors including lung cancer. In the present study, we analyzed TPTE-auto-antibodies in lung cancer patients.

METHODS:

Using a crude-lysate ELISA, we analyzed a large cohort of 307 sera from lung cancer patients and 47 healthy donors for TPTE-specific autoantibodies. Sero-reactivity was correlated with clinical parameters and patients' survival.

RESULTS:

TPTE-specific antibodies were detected in 41 of 307 (13.4%) sera from lung cancer patients. Based on an optimal cut-off value calculated by ROC curve analysis sensitivity for diagnosing lung cancer was 52% and specificity was 72%. TPTE sero-positivity was not associated with tumor stage, tumor histology, gender or age. Multivariate analysis indicated that TPTE sero-positivity is associated with prolonged survival in patients with lung cancer, but established prognostic factors for survival prediction such as stage and histology remain indispensable.

CONCLUSION:

Autoantibodies against TPTE occur spontaneously in lung cancer patients. TPTE sero-reactivity has moderate sensitivity and specificity for diagnosing lung cancer and is a positive prognostic marker.

KEYWORDS:

Cancer/testis antigen; NSCLC; NY-ESO 1; Prognosis; Serology; TPTE

PMID:
26350112
DOI:
10.1016/j.lungcan.2015.07.012
[Indexed for MEDLINE]

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