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Items: 1 to 20 of 84

1.

Ataluren, a New Therapeutic for Alpha-1 Antitrypsin Deficient Individuals with Nonsense Mutations.

Reeves EP, O'Dwyer CA, Dunlea DM, Wormald MR, Hawkins P, Alfares M, Kotton DN, Rowe SM, Wilson AA, McElvaney NG.

Am J Respir Crit Care Med. 2018 Jul 16. doi: 10.1164/rccm.201802-0338LE. [Epub ahead of print] No abstract available.

PMID:
30011228
2.

Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium.

McCauley KB, Alysandratos KD, Jacob A, Hawkins F, Caballero IS, Vedaie M, Yang W, Slovik KJ, Morley M, Carraro G, Kook S, Guttentag SH, Stripp BR, Morrisey EE, Kotton DN.

Stem Cell Reports. 2018 May 8;10(5):1579-1595. doi: 10.1016/j.stemcr.2018.03.013. Epub 2018 Apr 12.

3.

Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation.

Kotton DN.

J Clin Invest. 2018 Mar 1;128(3):903-905. doi: 10.1172/JCI99799. Epub 2018 Feb 5.

4.

Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells.

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, Na CL, Weaver TE, Vedaie M, Hurley K, Hinds A, Russo SJ, Kook S, Zacharias W, Ochs M, Traber K, Quinton LJ, Crane A, Davis BR, White FV, Wambach J, Whitsett JA, Cole FS, Morrisey EE, Guttentag SH, Beers MF, Kotton DN.

Cell Stem Cell. 2017 Oct 5;21(4):472-488.e10. doi: 10.1016/j.stem.2017.08.014. Epub 2017 Sep 28.

PMID:
28965766
5.

Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification.

Serra M, Alysandratos KD, Hawkins F, McCauley KB, Jacob A, Choi J, Caballero IS, Vedaie M, Kurmann AA, Ikonomou L, Hollenberg AN, Shannon JM, Kotton DN.

Development. 2017 Nov 1;144(21):3879-3893. doi: 10.1242/dev.150193. Epub 2017 Sep 25.

6.

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y.

Biomaterials. 2017 Dec;147:116-132. doi: 10.1016/j.biomaterials.2017.09.019. Epub 2017 Sep 19.

PMID:
28942128
7.

Interview with Darrell Kotton.

Kotton D.

Regen Med. 2017 Apr;12(4):337-338. doi: 10.2217/rme-2017-0054. Epub 2017 Jun 16.

PMID:
28621167
8.

Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells.

Hawkins F, Kramer P, Jacob A, Driver I, Thomas DC, McCauley KB, Skvir N, Crane AM, Kurmann AA, Hollenberg AN, Nguyen S, Wong BG, Khalil AS, Huang SX, Guttentag S, Rock JR, Shannon JM, Davis BR, Kotton DN.

J Clin Invest. 2017 Jun 1;127(6):2277-2294. doi: 10.1172/JCI89950. Epub 2017 May 2.

9.

TASIC: determining branching models from time series single cell data.

Rashid S, Kotton DN, Bar-Joseph Z.

Bioinformatics. 2017 Aug 15;33(16):2504-2512. doi: 10.1093/bioinformatics/btx173.

PMID:
28379537
10.

Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity.

Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP.

J Infect Dis. 2017 Aug 15;216(4):425-435. doi: 10.1093/infdis/jix159.

PMID:
28368460
11.

Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.

McCauley KB, Hawkins F, Serra M, Thomas DC, Jacob A, Kotton DN.

Cell Stem Cell. 2017 Jun 1;20(6):844-857.e6. doi: 10.1016/j.stem.2017.03.001. Epub 2017 Mar 30.

12.

Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1.

Dame K, Cincotta S, Lang AH, Sanghrajka RM, Zhang L, Choi J, Kwok L, Wilson T, Kańduła MM, Monti S, Hollenberg AN, Mehta P, Kotton DN, Ikonomou L.

Stem Cell Reports. 2017 Feb 14;8(2):216-225. doi: 10.1016/j.stemcr.2016.12.024. Epub 2017 Feb 2.

13.

Regenerative therapy for hypothyroidism: Mechanisms and possibilities.

Hollenberg AN, Choi J, Serra M, Kotton DN.

Mol Cell Endocrinol. 2017 Apr 15;445:35-41. doi: 10.1016/j.mce.2016.11.012. Epub 2016 Nov 19. Review.

14.

Unstable neurons underlie a stable learned behavior.

Liberti WA 3rd, Markowitz JE, Perkins LN, Liberti DC, Leman DP, Guitchounts G, Velho T, Kotton DN, Lois C, Gardner TJ.

Nat Neurosci. 2016 Dec;19(12):1665-1671. doi: 10.1038/nn.4405. Epub 2016 Oct 10.

15.

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.

Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN.

Cell Stem Cell. 2015 Nov 5;17(5):527-42. doi: 10.1016/j.stem.2015.09.004. Epub 2015 Oct 22.

16.

An official American Thoracic Society workshop report: stem cells and cell therapies in lung biology and diseases.

Weiss DJ, Chambers D, Giangreco A, Keating A, Kotton D, Lelkes PI, Wagner DE, Prockop DJ; ATS Subcommittee on Stem Cells and Cell Therapies.

Ann Am Thorac Soc. 2015 Apr;12(4):S79-97. doi: 10.1513/AnnalsATS.201502-086ST.

17.

Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Wilson AA, Ying L, Liesa M, Segeritz CP, Mills JA, Shen SS, Jean J, Lonza GC, Liberti DC, Lang AH, Nazaire J, Gower AC, Müeller FJ, Mehta P, Ordóñez A, Lomas DA, Vallier L, Murphy GJ, Mostoslavsky G, Spira A, Shirihai OS, Ramirez MI, Gadue P, Kotton DN.

Stem Cell Reports. 2015 May 12;4(5):873-85. doi: 10.1016/j.stemcr.2015.02.021. Epub 2015 Apr 2.

18.

Embryonic and induced pluripotent stem cells for lung regeneration.

Hawkins F, Kotton DN.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S50-3. doi: 10.1513/AnnalsATS.201410-457MG. Review.

PMID:
25830836
19.

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

Crane AM, Kramer P, Bui JH, Chung WJ, Li XS, Gonzalez-Garay ML, Hawkins F, Liao W, Mora D, Choi S, Wang J, Sun HC, Paschon DE, Guschin DY, Gregory PD, Kotton DN, Holmes MC, Sorscher EJ, Davis BR.

Stem Cell Reports. 2015 Apr 14;4(4):569-77. doi: 10.1016/j.stemcr.2015.02.005. Epub 2015 Mar 12.

20.

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency.

Tafaleng EN, Chakraborty S, Han B, Hale P, Wu W, Soto-Gutierrez A, Feghali-Bostwick CA, Wilson AA, Kotton DN, Nagaya M, Strom SC, Roy-Chowdhury J, Stolz DB, Perlmutter DH, Fox IJ.

Hepatology. 2015 Jul;62(1):147-57. doi: 10.1002/hep.27753. Epub 2015 Apr 13.

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