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Items: 1 to 20 of 134


Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes.

Gottlieb CD, Thompson ACS, Ordureau A, Harper JW, Kopito RR.

J Biol Chem. 2019 Nov 8;294(45):16511-16524. doi: 10.1074/jbc.RA119.009654. Epub 2019 Aug 2.


Methods for genetic analysis of mammalian ER-associated degradation.

Leto DE, Kopito RR.

Methods Enzymol. 2019;619:97-120. doi: 10.1016/bs.mie.2019.01.006. Epub 2019 Feb 20.


Ribosomal protein RPL26 is the principal target of UFMylation.

Walczak CP, Leto DE, Zhang L, Riepe C, Muller RY, DaRosa PA, Ingolia NT, Elias JE, Kopito RR.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1299-1308. doi: 10.1073/pnas.1816202116. Epub 2019 Jan 9.


Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation.

Leto DE, Morgens DW, Zhang L, Walczak CP, Elias JE, Bassik MC, Kopito RR.

Mol Cell. 2019 Jan 17;73(2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. Epub 2018 Dec 20.


Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors.

Pataki CI, Rodrigues J, Zhang L, Qian J, Efron B, Hastie T, Elias JE, Levitt M, Kopito RR.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8172-E8180. doi: 10.1073/pnas.1807981115. Epub 2018 Aug 13.


Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.

van der Goot AT, Pearce MMP, Leto DE, Shaler TA, Kopito RR.

Mol Cell. 2018 May 3;70(3):516-530.e6. doi: 10.1016/j.molcel.2018.03.026. Epub 2018 Apr 26.


Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.

Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR.

J Biol Chem. 2017 Jun 2;292(22):9104-9116. doi: 10.1074/jbc.M117.785055. Epub 2017 Apr 14.


Protein misfolding in neurodegenerative diseases: implications and strategies.

Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G, Venkateswaran A, Nurmi A, Hodgson R.

Transl Neurodegener. 2017 Mar 13;6:6. doi: 10.1186/s40035-017-0077-5. eCollection 2017. Review.


Prion-Like Characteristics of Polyglutamine-Containing Proteins.

Pearce MMP, Kopito RR.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a024257. doi: 10.1101/cshperspect.a024257. Review.


Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response.

Ben Yehuda A, Risheq M, Novoplansky O, Bersuker K, Kopito RR, Goldberg M, Brandeis M.

PLoS One. 2017 Jan 4;12(1):e0169054. doi: 10.1371/journal.pone.0169054. eCollection 2017.


Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.

Schrul B, Kopito RR.

Nat Cell Biol. 2016 Jul;18(7):740-51. doi: 10.1038/ncb3373. Epub 2016 Jun 13.


Ron R. Kopito: Unfolding the Secrets of Protein Aggregation.

Kopito RR.

Trends Cell Biol. 2016 Aug;26(8):559-560. doi: 10.1016/j.tcb.2016.05.001. Epub 2016 May 27. No abstract available.


Protein misfolding specifies recruitment to cytoplasmic inclusion bodies.

Bersuker K, Brandeis M, Kopito RR.

J Cell Biol. 2016 Apr 25;213(2):229-41. doi: 10.1083/jcb.201511024.


Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.

Pearce MMP, Spartz EJ, Hong W, Luo L, Kopito RR.

Nat Commun. 2015 Apr 13;6:6768. doi: 10.1038/ncomms7768.


Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease.

Bersuker K, Hipp MS, Calamini B, Morimoto RI, Kopito RR.

J Biol Chem. 2013 Aug 16;288(33):23633-8. doi: 10.1074/jbc.C113.481945. Epub 2013 Jul 9.


Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics.

Streets AM, Sourigues Y, Kopito RR, Melki R, Quake SR.

PLoS One. 2013;8(1):e54541. doi: 10.1371/journal.pone.0054541. Epub 2013 Jan 17.


Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

Olzmann JA, Richter CM, Kopito RR.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1345-50. doi: 10.1073/pnas.1213738110. Epub 2013 Jan 7.


The mammalian endoplasmic reticulum-associated degradation system.

Olzmann JA, Kopito RR, Christianson JC.

Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9). pii: a013185. doi: 10.1101/cshperspect.a013185. Review.


ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding.

Dowlatshahi DP, Sandrin V, Vivona S, Shaler TA, Kaiser SE, Melandri F, Sundquist WI, Kopito RR.

Dev Cell. 2012 Dec 11;23(6):1247-54. doi: 10.1016/j.devcel.2012.10.023. Epub 2012 Nov 29.


Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.

Tyler RE, Pearce MM, Shaler TA, Olzmann JA, Greenblatt EJ, Kopito RR.

Mol Biol Cell. 2012 Dec;23(24):4668-78. doi: 10.1091/mbc.E12-06-0428. Epub 2012 Oct 24.

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