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Oncotarget. 2016 Jul 12;7(28):42873-42880. doi: 10.18632/oncotarget.10146.

Do human B-lymphocytes avoid aging until 60 years?

Author information

1
Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.
2
Gamma-Delta T Cell Laboratory, University Hospital Brno, Brno, Czech Republic.
3
Laboratory of Cancer Biology and Genetics, University Hospital Brno, Brno, Czech Republic.
4
Department of Clinical Haematology, University Hospital Brno, Brno, Czech Republic.
5
Department of Internal Medicine, Haematology and Oncology, University Hospital Brno, Brno, Czech Republic.

Abstract

Broad changes in human innate and adaptive immunity are associated with advanced age. The age-related alteration of gene expression was reported for both T and B lymphocytes. We analysed the genome-wide expression profiles (n=20) of naive and whole B cell populations from young and early aged healthy donors under 60 years. We revealed large homogeneity of all analysed genome-wide expression profiles but did not identified any significant gene deregulation between young (30-45 years) and early aged healthy donors (50-60 years). We argue that B cells avoid the aging program on molecular level until 60 years of age. Our results demonstrate the potential of hematopoietic stem cells to generate uncompromised lymphocytes in early elderly. These are very encouraging findings for the general health and the immunity maintenance would not need any intervention to naive B cells. Rather, a suitable immune stimulation in healthy body environment warrants further research into aging of older elderly.

KEYWORDS:

B cell; GEP; Gerotarget; IL7R; aging; naive B cells

PMID:
27344181
PMCID:
PMC5189993
DOI:
10.18632/oncotarget.10146
[Indexed for MEDLINE]
Free PMC Article

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