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Items: 1 to 20 of 125


Unilateral ex vivo gene therapy by GDNF in epileptic rats.

Nanobashvili A, Melin E, Emerich D, Tornøe J, Simonato M, Wahlberg L, Kokaia M.

Gene Ther. 2018 Nov 21. doi: 10.1038/s41434-018-0050-7. [Epub ahead of print]


Dynamic interaction of local and transhemispheric networks is necessary for progressive intensification of hippocampal seizures.

Berglind F, Andersson M, Kokaia M.

Sci Rep. 2018 Apr 4;8(1):5669. doi: 10.1038/s41598-018-23659-x.


Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery.

Wickham J, Brödjegård NG, Vighagen R, Pinborg LH, Bengzon J, Woldbye DPD, Kokaia M, Andersson M.

Sci Rep. 2018 Mar 7;8(1):4158. doi: 10.1038/s41598-018-22554-9.


Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons.

Sørensen AT, Ledri M, Melis M, Nikitidou Ledri L, Andersson M, Kokaia M.

eNeuro. 2018 Jan 23;4(6). pii: ENEURO.0172-17.2017. doi: 10.1523/ENEURO.0172-17.2017. eCollection 2017 Nov-Dec.


Preserved Function of Afferent Parvalbumin-Positive Perisomatic Inhibitory Synapses of Dentate Granule Cells in Rapidly Kindled Mice.

Hansen MG, Ledri LN, Kirik D, Kokaia M, Ledri M.

Front Cell Neurosci. 2018 Jan 9;11:433. doi: 10.3389/fncel.2017.00433. eCollection 2017.


Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus.

Avaliani N, Pfisterer U, Heuer A, Parmar M, Kokaia M, Andersson M.

Stem Cells Int. 2017;2017:5718608. doi: 10.1155/2017/5718608. Epub 2017 Nov 26.


Epilepsy and optogenetics: can seizures be controlled by light?

Tønnesen J, Kokaia M.

Clin Sci (Lond). 2017 Jun 30;131(14):1605-1616. doi: 10.1042/CS20160492. Print 2017 Jul 15. Review.


Common data elements and data management: Remedy to cure underpowered preclinical studies.

Lapinlampi N, Melin E, Aronica E, Bankstahl JP, Becker A, Bernard C, Gorter JA, Gröhn O, Lipsanen A, Lukasiuk K, Löscher W, Paananen J, Ravizza T, Roncon P, Simonato M, Vezzani A, Kokaia M, Pitkänen A.

Epilepsy Res. 2017 Jan;129:87-90. doi: 10.1016/j.eplepsyres.2016.11.010. Epub 2016 Nov 22.


DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue.

Avaliani N, Andersson M, Runegaard AH, Woldbye D, Kokaia M.

Gene Ther. 2016 Oct;23(10):760-766. doi: 10.1038/gt.2016.56. Epub 2016 Jul 14.


Short-Term Grafting of Human Neural Stem Cells: Electrophysiological Properties and Motor Behavioral Amelioration in Experimental Parkinsons Disease.

Martnez-Serrano A, Pereira MP, Avaliani N, Nelke A, Kokaia M, Ramos-Moreno T.

Cell Transplant. 2016 Dec 13;25(12):2083-2097. doi: 10.3727/096368916X692069. Epub 2016 Jun 17.


Advances in the development of biomarkers for epilepsy.

Pitkänen A, Löscher W, Vezzani A, Becker AJ, Simonato M, Lukasiuk K, Gröhn O, Bankstahl JP, Friedman A, Aronica E, Gorter JA, Ravizza T, Sisodiya SM, Kokaia M, Beck H.

Lancet Neurol. 2016 Jul;15(8):843-856. doi: 10.1016/S1474-4422(16)00112-5. Review.


Optogenetic control of human neurons in organotypic brain cultures.

Andersson M, Avaliani N, Svensson A, Wickham J, Pinborg LH, Jespersen B, Christiansen SH, Bengzon J, Woldbye DP, Kokaia M.

Sci Rep. 2016 Apr 21;6:24818. doi: 10.1038/srep24818.


Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.

Ledri LN, Melin E, Christiansen SH, Gøtzsche CR, Cifra A, Woldbye DP, Kokaia M.

Neurobiol Dis. 2016 Feb;86:52-61. doi: 10.1016/j.nbd.2015.11.014. Epub 2015 Dec 1.


Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.

Ledri M, Sørensen AT, Madsen MG, Christiansen SH, Ledri LN, Cifra A, Bengzon J, Lindberg E, Pinborg LH, Jespersen B, Gøtzsche CR, Woldbye DP, Andersson M, Kokaia M.

J Neurosci. 2015 Jul 1;35(26):9622-31. doi: 10.1523/JNEUROSCI.3973-14.2015.


WONOEP appraisal: optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis.

Mantoan Ritter L, Golshani P, Takahashi K, Dufour S, Valiante T, Kokaia M.

Epilepsia. 2014 Nov;55(11):1693-702. doi: 10.1111/epi.12804. Epub 2014 Oct 9. Review.


Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors.

Avaliani N, Sørensen AT, Ledri M, Bengzon J, Koch P, Brüstle O, Deisseroth K, Andersson M, Kokaia M.

Stem Cells. 2014 Dec;32(12):3088-98. doi: 10.1002/stem.1823.


How might novel technologies such as optogenetics lead to better treatments in epilepsy?

Krook-Magnuson E, Ledri M, Soltesz I, Kokaia M.

Adv Exp Med Biol. 2014;813:319-36. doi: 10.1007/978-94-017-8914-1_26. Review.


Global optogenetic activation of inhibitory interneurons during epileptiform activity.

Ledri M, Madsen MG, Nikitidou L, Kirik D, Kokaia M.

J Neurosci. 2014 Feb 26;34(9):3364-77. doi: 10.1523/JNEUROSCI.2734-13.2014.


Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

Berglind F, Ledri M, Sørensen AT, Nikitidou L, Melis M, Bielefeld P, Kirik D, Deisseroth K, Andersson M, Kokaia M.

Neurobiol Dis. 2014 May;65:133-41. doi: 10.1016/j.nbd.2014.01.015. Epub 2014 Jan 31.


Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus.

Nikitidou L, Torp M, Fjord-Larsen L, Kusk P, Wahlberg LU, Kokaia M.

Epilepsia. 2014 Jan;55(1):167-74. doi: 10.1111/epi.12470. Epub 2013 Nov 18.

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