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J Oral Maxillofac Pathol. 2014 Sep-Dec;18(3):361-4. doi: 10.4103/0973-029X.151313.

Detection of salivary interleukin-2 in recurrent aphthous stomatitis.

Author information

1
Department of Oral and Maxillofacial Pathology, Rathnavel Subramaniam Educational Trust RVS Dental College and Hospital, Kannampalayam, Sulur, Coimbatore, India.
2
Department of Oral and Maxillofacial Pathology, Meenakshi Ammal Dental College and Hospital, Chennai, Tamil Nadu, India.

Abstract

OBJECTIVE:

The present study was undertaken to estimate and compare salivary interleukin-2 (IL-2) levels in patients with recurrent aphthous stomatitis, among healthy controls and their variation with age and sex.

STUDY DESIGN:

Saliva was collected from 60 patients within the age range of 16-60 years which included 30 patients (17 Females and 13 Males) with recurrent aphthous stomatitis and healthy control group consisted of 30 participants (18 Females and 12 Males). IL-2 estimation was done in both the groups using enzyme linked immunosorbent assay (ELISA). Statistical analysis of the data was done using Independent 't' test.

RESULTS:

The results showed increased salivary IL-2 levels in patients with recurrent aphthous stomatitis compared to the healthy controls. The IL-2 levels were also increased in patients with the age group of 16-30 years compared to other age groups. Similar increase of IL-2 was also seen in female patients.

CONCLUSION:

Age related and sex related alterations of IL-2 in recurrent aphthous stomatitis patients were observed.

KEYWORDS:

Enzyme linked immunosorbent assay; interleukin-2; recurrent aphthous stomatitis

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