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Methods and approaches to disease mechanisms using systems kinomics.

Berard A, Kroeker A, McQueen P, Coombs KM.

Synth Syst Biotechnol. 2017 Dec 18;3(1):34-43. doi: 10.1016/j.synbio.2017.12.004. eCollection 2018 Mar. Review.


Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus.

Ranadheera C, Coombs KM, Kobasa D.

EBioMedicine. 2018 Jun;32:142-163. doi: 10.1016/j.ebiom.2018.05.027. Epub 2018 Jun 2.


Avian influenza viruses that cause highly virulent infections in humans exhibit distinct replicative properties in contrast to human H1N1 viruses.

Simon PF, de La Vega MA, Paradis É, Mendoza E, Coombs KM, Kobasa D, Beauchemin CA.

Sci Rep. 2016 Apr 15;6:24154. doi: 10.1038/srep24154.


New use of an old drug: chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial).

Peymani P, Yeganeh B, Sabour S, Geramizadeh B, Fattahi MR, Keyvani H, Azarpira N, Coombs KM, Ghavami S, Lankarani KB.

Can J Physiol Pharmacol. 2016 Jun;94(6):613-9. doi: 10.1139/cjpp-2015-0507. Epub 2016 Jan 15.


Apoptosis, autophagy and unfolded protein response pathways in Arbovirus replication and pathogenesis.

Iranpour M, Moghadam AR, Yazdi M, Ande SR, Alizadeh J, Wiechec E, Lindsay R, Drebot M, Coombs KM, Ghavami S.

Expert Rev Mol Med. 2016 Jan 19;18:e1. doi: 10.1017/erm.2015.19. Review.


Highly Pathogenic H5N1 and Novel H7N9 Influenza A Viruses Induce More Profound Proteomic Host Responses than Seasonal and Pandemic H1N1 Strains.

Simon PF, McCorrister S, Hu P, Chong P, Silaghi A, Westmacott G, Coombs KM, Kobasa D.

J Proteome Res. 2015 Nov 6;14(11):4511-23. doi: 10.1021/acs.jproteome.5b00196. Epub 2015 Oct 9.


Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.

Berard AR, Severini A, Coombs KM.

J Virol. 2015 Dec;89(23):11954-64. doi: 10.1128/JVI.01639-15. Epub 2015 Sep 16.


Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells.

Ezzati P, Komher K, Severini G, Coombs KM.

Front Cell Infect Microbiol. 2015 Apr 7;5:30. doi: 10.3389/fcimb.2015.00030. eCollection 2015.


Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.

Berard AR, Severini A, Coombs KM.

Proteomics. 2015 Jun;15(12):2113-35. doi: 10.1002/pmic.201400602. Epub 2015 May 26.


Quantification of the host response proteome after herpes simplex virus type 1 infection.

Berard AR, Coombs KM, Severini A.

J Proteome Res. 2015 May 1;14(5):2121-42. doi: 10.1021/pr5012284. Epub 2015 Apr 15.


Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.

Yeganeh B, Ghavami S, Kroeker AL, Mahood TH, Stelmack GL, Klonisch T, Coombs KM, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L270-86. doi: 10.1152/ajplung.00011.2014. Epub 2014 Oct 31.


Proteasomal serine hydrolases are up-regulated by and required for influenza virus infection.

Shahiduzzaman M, Ezatti P, Xin G, Coombs KM.

J Proteome Res. 2014 May 2;13(5):2223-38. doi: 10.1021/pr5001779. Epub 2014 Apr 7.


Systems biology unravels interferon responses to respiratory virus infections.

Kroeker AL, Coombs KM.

World J Biol Chem. 2014 Feb 26;5(1):12-25. doi: 10.4331/wjbc.v5.i1.12. Review.


HeLa cell response proteome alterations induced by mammalian reovirus T3D infection.

Coombs KM.

Virol J. 2013 Jun 21;10:202. doi: 10.1186/1743-422X-10-202.


Influenza A infection of primary human airway epithelial cells up-regulates proteins related to purine metabolism and ubiquitin-related signaling.

Kroeker AL, Ezzati P, Coombs KM, Halayko AJ.

J Proteome Res. 2013 Jul 5;12(7):3139-51. doi: 10.1021/pr400464p. Epub 2013 Jun 21.


Asthma and influenza virus infection:focusing on cell death and stress pathways in influenza virus replication.

Yeganeh B, Rezaei Moghadam A, Tran AT, Rahim MN, Ande SR, Hashemi M, Coombs KM, Ghavami S.

Iran J Allergy Asthma Immunol. 2013 Mar;12(1):1-17. doi: 012.01/ijaai.117. Review.


Quantification of the host response proteome after mammalian reovirus T1L infection.

Berard AR, Cortens JP, Krokhin O, Wilkins JA, Severini A, Coombs KM.

PLoS One. 2012;7(12):e51939. doi: 10.1371/journal.pone.0051939. Epub 2012 Dec 11.


Generation and characterization of a new panel of broadly reactive anti-NS1 mAbs for detection of influenza A virus.

Rahim MN, Selman M, Sauder PJ, Forbes NE, Stecho W, Xu W, Lebar M, Brown EG, Coombs KM.

J Gen Virol. 2013 Mar;94(Pt 3):593-605. doi: 10.1099/vir.0.046649-0. Epub 2012 Dec 5.


Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation.

Tran AT, Cortens JP, Du Q, Wilkins JA, Coombs KM.

J Virol. 2013 Jan;87(2):1049-60. doi: 10.1128/JVI.02017-12. Epub 2012 Nov 7.


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