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Items: 1 to 20 of 101

1.

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.

Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan MH, Kelley MR, Tell G, Pucillo CEM.

J Biol Chem. 2019 Mar 29;294(13):5198-5207. doi: 10.1074/jbc.RA118.006601. Epub 2019 Jan 31.

PMID:
30705092
2.

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA Jr, Kelley MR, Georgiadis MM.

J Med Chem. 2019 Feb 28;62(4):1971-1988. doi: 10.1021/acs.jmedchem.8b01529. Epub 2019 Feb 6.

PMID:
30653918
3.

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.

Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R.

Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013.

PMID:
30526882
4.

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.

Sci Rep. 2018 Sep 13;8(1):13759. doi: 10.1038/s41598-018-32034-9.

5.

Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.

Sardar Pasha SPB, Sishtla K, Sulaiman RS, Park B, Shetty T, Shah F, Fishel ML, Wikel JH, Kelley MR, Corson TW.

J Pharmacol Exp Ther. 2018 Oct;367(1):108-118. doi: 10.1124/jpet.118.248088. Epub 2018 Aug 3.

PMID:
30076264
6.

APX3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats.

Yan T, Venkat P, Chopp M, Zacharek A, Yu P, Ning R, Qiao X, Kelley MR, Chen J.

Aging Dis. 2018 Jun 1;9(3):453-466. doi: 10.14336/AD.2017.1130. eCollection 2018 Jun.

7.

APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells.

McIlwain DW, Fishel ML, Boos A, Kelley MR, Jerde TJ.

Oncotarget. 2017 Dec 13;9(13):10962-10977. doi: 10.18632/oncotarget.23493. eCollection 2018 Feb 16.

8.

DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.

Fehrenbacher JC, Guo C, Kelley MR, Vasko MR.

Neuroscience. 2017 Dec 16;366:23-35. doi: 10.1016/j.neuroscience.2017.09.039. Epub 2017 Sep 28.

9.

APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.

Shah F, Goossens E, Atallah NM, Grimard M, Kelley MR, Fishel ML.

Mol Oncol. 2017 Dec;11(12):1711-1732. doi: 10.1002/1878-0261.12138. Epub 2017 Oct 19.

10.

Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.

Shah F, Logsdon D, Messmann RA, Fehrenbacher JC, Fishel ML, Kelley MR.

NPJ Precis Oncol. 2017;1. pii: 19. doi: 10.1038/s41698-017-0023-0. Epub 2017 Jun 8.

11.

Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.

Ding J, Fishel ML, Reed AM, McAdams E, Czader MB, Cardoso AA, Kelley MR.

Mol Cancer Ther. 2017 Jul;16(7):1401-1411. doi: 10.1158/1535-7163.MCT-17-0099. Epub 2017 Apr 26.

12.

Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage.

Kelley MR, Fehrenbacher JC.

Neural Regen Res. 2017 Jan;12(1):72-74. doi: 10.4103/1673-5374.198986. No abstract available.

13.

Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.

Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML.

Mol Cancer Ther. 2016 Nov;15(11):2722-2732. Epub 2016 Aug 17.

14.

Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.

Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR.

J Pharmacol Exp Ther. 2016 Nov;359(2):300-309. Epub 2016 Sep 8.

15.

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons.

Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR.

DNA Repair (Amst). 2016 May;41:32-41. doi: 10.1016/j.dnarep.2016.03.009. Epub 2016 Mar 29.

16.

APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER.

Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH.

Mutat Res. 2015 Sep;779:96-104. doi: 10.1016/j.mrfmmm.2015.06.010. Epub 2015 Jun 26.

17.

Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.

Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M, He Y, Yu Z, Tong Y, Lipking KP, Maitra A, Rajeshkumar NV, Scandura G, Kelley MR, Ivan M.

J Biol Chem. 2015 Jan 30;290(5):3057-68. doi: 10.1074/jbc.M114.621995. Epub 2014 Dec 9.

18.

Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice.

Shannon HE, Fishel ML, Xie J, Gu D, McCarthy BP, Riley AA, Sinn AL, Silver JM, Peterman K, Kelley MR, Hanenberg H, Korc M, Pollok KE, Territo PR.

Pancreas. 2015 Jan;44(1):64-75. doi: 10.1097/MPA.0000000000000238.

19.

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.

Kelley MR, Jiang Y, Guo C, Reed A, Meng H, Vasko MR.

PLoS One. 2014 Sep 4;9(9):e106485. doi: 10.1371/journal.pone.0106485. eCollection 2014.

20.

Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.

Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4461-9. doi: 10.1167/iovs.14-14451.

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