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Items: 1 to 20 of 22

1.

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.

Kell DB, Pretorius E.

Biol Rev Camb Philos Soc. 2018 Aug;93(3):1518-1557. doi: 10.1111/brv.12407. Epub 2018 Mar 25.

2.

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease.

Pretorius E, Page MJ, Mbotwe S, Kell DB.

PLoS One. 2018 Mar 1;13(3):e0192121. doi: 10.1371/journal.pone.0192121. eCollection 2018.

3.

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains.

Pretorius E, Page MJ, Hendricks L, Nkosi NB, Benson SR, Kell DB.

J R Soc Interface. 2018 Feb;15(139). pii: 20170941. doi: 10.1098/rsif.2017.0941.

4.

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains.

Pretorius E, Page MJ, Engelbrecht L, Ellis GC, Kell DB.

Cardiovasc Diabetol. 2017 Nov 2;16(1):141. doi: 10.1186/s12933-017-0624-5.

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Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability.

Pretorius E, Akeredolu OO, Soma P, Kell DB.

Exp Biol Med (Maywood). 2017 Feb;242(4):355-373. doi: 10.1177/1535370216681549. Epub 2016 Nov 26. Review.

8.

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide.

Pretorius E, Mbotwe S, Bester J, Robinson CJ, Kell DB.

J R Soc Interface. 2016 Sep;13(122). pii: 20160539. doi: 10.1098/rsif.2016.0539.

9.

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting.

Kell DB, Pretorius E.

Prog Biophys Mol Biol. 2017 Jan;123:16-41. doi: 10.1016/j.pbiomolbio.2016.08.006. Epub 2016 Aug 21. Review.

10.

A Bacterial Component to Alzheimer's-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease.

Pretorius E, Bester J, Kell DB.

J Alzheimers Dis. 2016 Jun 18;53(4):1237-56. doi: 10.3233/JAD-160318. Review.

11.

Microbes and Alzheimer's Disease.

Itzhaki RF, Lathe R, Balin BJ, Ball MJ, Bearer EL, Braak H, Bullido MJ, Carter C, Clerici M, Cosby SL, Del Tredici K, Field H, Fulop T, Grassi C, Griffin WS, Haas J, Hudson AP, Kamer AR, Kell DB, Licastro F, Letenneur L, Lövheim H, Mancuso R, Miklossy J, Otth C, Palamara AT, Perry G, Preston C, Pretorius E, Strandberg T, Tabet N, Taylor-Robinson SD, Whittum-Hudson JA.

J Alzheimers Dis. 2016;51(4):979-84. doi: 10.3233/JAD-160152. Review. No abstract available.

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14.

The dormant blood microbiome in chronic, inflammatory diseases.

Potgieter M, Bester J, Kell DB, Pretorius E.

FEMS Microbiol Rev. 2015 Jul;39(4):567-91. doi: 10.1093/femsre/fuv013. Epub 2015 May 3. Review.

15.

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics.

Pretorius E, Bester J, Vermeulen N, Alummoottil S, Soma P, Buys AV, Kell DB.

Cardiovasc Diabetol. 2015 Mar 8;14:30. doi: 10.1186/s12933-015-0192-5.

16.

Eryptosis as a marker of Parkinson's disease.

Pretorius E, Swanepoel AC, Buys AV, Vermeulen N, Duim W, Kell DB.

Aging (Albany NY). 2014 Oct;6(10):788-819.

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18.

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases.

Pretorius E, Kell DB.

Integr Biol (Camb). 2014 May;6(5):486-510. doi: 10.1039/c4ib00025k. Review.

PMID:
24714688
19.

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells.

Kell DB, Pretorius E.

Metallomics. 2014 Apr;6(4):748-73. doi: 10.1039/c3mt00347g.

PMID:
24549403
20.

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.

Pretorius E, Bester J, Vermeulen N, Lipinski B, Gericke GS, Kell DB.

PLoS One. 2014 Jan 9;9(1):e85271. doi: 10.1371/journal.pone.0085271. eCollection 2014.

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