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Association of Early-Life Antibiotic Use and Protective Effects of Breastfeeding: Role of the Intestinal Microbiota.

Korpela K, Salonen A, Virta LJ, Kekkonen RA, de Vos WM.

JAMA Pediatr. 2016 Aug 1;170(8):750-7. doi: 10.1001/jamapediatrics.2016.0585.


Lactobacillus rhamnosus GG Intake Modifies Preschool Children's Intestinal Microbiota, Alleviates Penicillin-Associated Changes, and Reduces Antibiotic Use.

Korpela K, Salonen A, Virta LJ, Kumpu M, Kekkonen RA, de Vos WM.

PLoS One. 2016 Apr 25;11(4):e0154012. doi: 10.1371/journal.pone.0154012. eCollection 2016.


Faecal Metaproteomic Analysis Reveals a Personalized and Stable Functional Microbiome and Limited Effects of a Probiotic Intervention in Adults.

Kolmeder CA, Salojärvi J, Ritari J, de Been M, Raes J, Falony G, Vieira-Silva S, Kekkonen RA, Corthals GL, Palva A, Salonen A, de Vos WM.

PLoS One. 2016 Apr 12;11(4):e0153294. doi: 10.1371/journal.pone.0153294. eCollection 2016.


Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children.

Korpela K, Salonen A, Virta LJ, Kekkonen RA, Forslund K, Bork P, de Vos WM.

Nat Commun. 2016 Jan 26;7:10410. doi: 10.1038/ncomms10410.


Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: randomised, double blind, placebo-controlled pilot trial.

Kumpu M, Kekkonen RA, Korpela R, Tynkkynen S, Järvenpää S, Kautiainen H, Allen EK, Hendley JO, Pitkäranta A, Winther B.

Benef Microbes. 2015;6(5):631-9. doi: 10.3920/BM2014.0164. Epub 2015 Aug 31.


Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study.

Holma R, Kekkonen RA, Hatakka K, Poussa T, Vapaatalo H, Adlercreutz H, Korpela R.

Br J Nutr. 2014 Jan 28;111(2):301-9. doi: 10.1017/S0007114513002420. Epub 2013 Aug 7.


Associations between the human intestinal microbiota, Lactobacillus rhamnosus GG and serum lipids indicated by integrated analysis of high-throughput profiling data.

Lahti L, Salonen A, Kekkonen RA, Salojärvi J, Jalanka-Tuovinen J, Palva A, Orešič M, de Vos WM.

PeerJ. 2013 Feb 26;1:e32. doi: 10.7717/peerj.32. Print 2013.


Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet.

Oksaharju A, Kooistra T, Kleemann R, van Duyvenvoorde W, Miettinen M, Lappalainen J, Lindstedt KA, Kovanen PT, Korpela R, Kekkonen RA.

Br J Nutr. 2013 Jul 14;110(1):77-85. doi: 10.1017/S0007114512004801. Epub 2012 Dec 5.


Recovery of probiotic Lactobacillus rhamnosus GG in tonsil tissue after oral administration: randomised, placebo-controlled, double-blind clinical trial.

Kumpu M, Swanljung E, Tynkkynen S, Hatakka K, Kekkonen RA, Järvenpää S, Korpela R, Pitkäranta A.

Br J Nutr. 2013 Jun 28;109(12):2240-6. doi: 10.1017/S0007114512004540. Epub 2012 Oct 24.


Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages.

Miettinen M, Pietilä TE, Kekkonen RA, Kankainen M, Latvala S, Pirhonen J, Österlund P, Korpela R, Julkunen I.

Gut Microbes. 2012 Nov-Dec;3(6):510-22. doi: 10.4161/gmic.21736. Epub 2012 Aug 16.


Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial.

Kumpu M, Kekkonen RA, Kautiainen H, Järvenpää S, Kristo A, Huovinen P, Pitkäranta A, Korpela R, Hatakka K.

Eur J Clin Nutr. 2012 Sep;66(9):1020-3. doi: 10.1038/ejcn.2012.62. Epub 2012 Jun 13.


Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome.

Rajilić-Stojanović M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM.

Gastroenterology. 2011 Nov;141(5):1792-801. doi: 10.1053/j.gastro.2011.07.043. Epub 2011 Aug 5.


Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages.

Latvala S, Miettinen M, Kekkonen RA, Korpela R, Julkunen I.

Clin Exp Immunol. 2011 Jul;165(1):94-103. doi: 10.1111/j.1365-2249.2011.04408.x. Epub 2011 May 5.


A probiotic mixture including galactooligosaccharides decreases fecal β-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention.

Kekkonen RA, Holma R, Hatakka K, Suomalainen T, Poussa T, Adlercreutz H, Korpela R.

J Nutr. 2011 May;141(5):870-6. doi: 10.3945/jn.110.137703. Epub 2011 Mar 16.


Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells.

Oksaharju A, Kankainen M, Kekkonen RA, Lindstedt KA, Kovanen PT, Korpela R, Miettinen M.

World J Gastroenterol. 2011 Feb 14;17(6):750-9. doi: 10.3748/wjg.v17.i6.750.


Comparative analysis of fecal DNA extraction methods with phylogenetic microarray: effective recovery of bacterial and archaeal DNA using mechanical cell lysis.

Salonen A, Nikkilä J, Jalanka-Tuovinen J, Immonen O, Rajilić-Stojanović M, Kekkonen RA, Palva A, de Vos WM.

J Microbiol Methods. 2010 May;81(2):127-34. doi: 10.1016/j.mimet.2010.02.007. Epub 2010 Feb 19.


Effects of a fibre-enriched milk drink on insulin and glucose levels in healthy subjects.

Lummela N, Kekkonen RA, Jauhiainen T, Pilvi TK, Tuure T, Järvenpää S, Eriksson JG, Korpela R.

Nutr J. 2009 Oct 1;8:45. doi: 10.1186/1475-2891-8-45.


Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells.

Latvala S, Pietila TE, Veckman V, Kekkonen RA, Tynkkynen S, Korpela R, Julkunen I.

World J Gastroenterol. 2008 Sep 28;14(36):5570-83; discussion 5581-2.


In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own.

Piirainen L, Kekkonen RA, Kajander K, Ahlroos T, Tynkkynen S, Nevala R, Korpela R.

Ann Nutr Metab. 2008;52(3):204-8. doi: 10.1159/000138124. Epub 2008 Jun 11.


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