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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1975 1
1976 1
1977 1
1978 1
1979 1
1981 1
1982 2
1983 6
1984 1
1985 1
1986 3
1987 3
1990 5
1991 2
1993 4
1994 1
1995 1
1996 2
1997 4
1998 4
1999 4
2000 4
2001 12
2002 20
2003 22
2004 28
2005 35
2006 30
2007 38
2008 29
2009 39
2010 43
2011 42
2012 40
2013 40
2014 43
2015 38
2016 42
2017 30
2018 24
2019 38
2020 42
2021 41
2022 39
2023 25
2024 13

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735 results

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Page 1
Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases.
Ohmuraya M, Yamamura K. Ohmuraya M, et al. Exp Anim. 2011;60(5):433-44. doi: 10.1538/expanim.60.433. Exp Anim. 2011. PMID: 22041280 Free article. Review.
Serine protease inhibitor Kazal type 1 (SPINK1) was originally identified as a trypsin inhibitor by Kazal et al. in 1948. ...These data indicate that the role of the SPINK1 is not just as a trypsin inhibitor, but also as a growth factor a …
Serine protease inhibitor Kazal type 1 (SPINK1) was originally identified as a trypsin inhibitor by Kazal …
Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine.
Chen YT, Tseng TT, Tsai HP, Kuo SH, Huang MY, Wang JY, Chai CY. Chen YT, et al. Hum Cell. 2022 Nov;35(6):1912-1927. doi: 10.1007/s13577-022-00776-4. Epub 2022 Sep 2. Hum Cell. 2022. PMID: 36053457 Free PMC article.
Serine peptidase inhibitor Kazal type-1 (SPINK1), a trypsin kinase inhibitor, is known to be associated with inflammation and pathogenesis. ...
Serine peptidase inhibitor Kazal type-1 (SPINK1), a trypsin kinase inhibitor, is known to be associated with inf …
Serine Protease Inhibitor Kazal Type 1, A Potential Biomarker for the Early Detection, Targeting, and Prediction of Response to Immune Checkpoint Blockade Therapies in Hepatocellular Carcinoma.
Jia J, Ga L, Liu Y, Yang Z, Wang Y, Guo X, Ma R, Liu R, Li T, Tang Z, Wang J. Jia J, et al. Front Immunol. 2022 Jul 18;13:923031. doi: 10.3389/fimmu.2022.923031. eCollection 2022. Front Immunol. 2022. PMID: 35924241 Free PMC article.
BACKGROUND: We aimed to characterize serine protease inhibitor Kazal type 1 (SPINK1) as a gene signature for the early diagnosis, molecular targeting, and prediction of immune checkpoint blockade (ICB) treatment response of hepatocellular carcinoma (HC …
BACKGROUND: We aimed to characterize serine protease inhibitor Kazal type 1 (SPINK1) as a gene signature for the …
Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor.
Walvekar VA, Ramesh K, Jobichen C, Kannan M, Sivaraman J, Kini RM, Mok YK. Walvekar VA, et al. Protein Sci. 2022 Feb;31(2):470-484. doi: 10.1002/pro.4245. Epub 2021 Nov 29. Protein Sci. 2022. PMID: 34800067 Free PMC article.
Kazal-type protease inhibitor specificity is believed to be determined by sequence of the reactive-site loop that make most, if not all, contacts with the serine protease. Here, we determined the complex crystal structure of Aedes aegypti trypsi …
Kazal-type protease inhibitor specificity is believed to be determined by sequence of the reactive-site loop tha …
Pancreatitis Overview.
Shelton C, LaRusch J, Whitcomb DC. Shelton C, et al. 2014 Mar 13 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2014 Mar 13 [updated 2020 Jul 2]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 24624459 Free Books & Documents. Review.
Juvenile hormone-dependent Kazal-type serine protease inhibitor Greglin safeguards insect vitellogenesis and egg production.
Guo W, Wu Z, Yang L, Cai Z, Zhao L, Zhou S. Guo W, et al. FASEB J. 2019 Jan;33(1):917-927. doi: 10.1096/fj.201801068R. Epub 2018 Jul 31. FASEB J. 2019. PMID: 30063437
By reanalyzing the transcriptomic data from adults and other developmental stages of the migratory locust Locusta migratoria, we identified a gene coding for Kazal-type protease inhibitor, previously named Greglin. Greglin is specifically expressed in …
By reanalyzing the transcriptomic data from adults and other developmental stages of the migratory locust Locusta migratoria, we identified …
The serine protease inhibitor of Kazal-type 7 (SPINK7) is expressed in human skin.
Weber C, Fischer J, Redelfs L, Rademacher F, Harder J, Weidinger S, Wu Z, Meyer-Hoffert U. Weber C, et al. Arch Dermatol Res. 2017 Nov;309(9):767-771. doi: 10.1007/s00403-017-1773-9. Epub 2017 Aug 29. Arch Dermatol Res. 2017. PMID: 28852849
Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. SPINK7 is a member of the SPINK protease inhibitor family and has been described so far as a cancer-related gene in the esopha …
Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. …
Genetic and Epigenetic Aspects of Atopic Dermatitis.
Nedoszytko B, Reszka E, Gutowska-Owsiak D, Trzeciak M, Lange M, Jarczak J, Niedoszytko M, Jablonska E, Romantowski J, Strapagiel D, Skokowski J, Siekierzycka A, Nowicki RJ, Dobrucki IT, Zaryczańska A, Kalinowski L. Nedoszytko B, et al. Int J Mol Sci. 2020 Sep 4;21(18):6484. doi: 10.3390/ijms21186484. Int J Mol Sci. 2020. PMID: 32899887 Free PMC article. Review.
Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental …
Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural …
735 results