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Items: 1 to 20 of 49

1.

Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.

Daigh LH, Liu C, Chung M, Cimprich KA, Meyer T.

Cell Syst. 2018 Jun 4. pii: S2405-4712(18)30229-1. doi: 10.1016/j.cels.2018.05.011. [Epub ahead of print]

PMID:
29909278
2.

Faulty replication can sting.

Crossley MP, Cimprich KA.

Nature. 2018 May;557(7703):34-35. doi: 10.1038/d41586-018-02804-6. No abstract available.

PMID:
29713064
3.

A new mitotic activity comes into focus.

Saldivar JC, Cimprich KA.

Science. 2018 Jan 5;359(6371):30-31. doi: 10.1126/science.aar4799. No abstract available.

PMID:
29302000
4.

Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome.

Saldivar JC, Cortez D, Cimprich KA.

Nat Rev Mol Cell Biol. 2017 Dec;18(12):783. doi: 10.1038/nrm.2017.116. Epub 2017 Nov 8. No abstract available.

PMID:
29115300
5.

The essential kinase ATR: ensuring faithful duplication of a challenging genome.

Saldivar JC, Cortez D, Cimprich KA.

Nat Rev Mol Cell Biol. 2017 Oct;18(10):622-636. doi: 10.1038/nrm.2017.67. Epub 2017 Aug 16. Review. Erratum in: Nat Rev Mol Cell Biol. 2017 Dec;18(12 ):783.

6.

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses.

Hamperl S, Bocek MJ, Saldivar JC, Swigut T, Cimprich KA.

Cell. 2017 Aug 10;170(4):774-786.e19. doi: 10.1016/j.cell.2017.07.043.

PMID:
28802045
7.

Conflict Resolution in the Genome: How Transcription and Replication Make It Work.

Hamperl S, Cimprich KA.

Cell. 2016 Dec 1;167(6):1455-1467. doi: 10.1016/j.cell.2016.09.053. Review.

8.

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.

Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC.

Nat Methods. 2016 Dec;13(12):1036-1042. doi: 10.1038/nmeth.4038. Epub 2016 Oct 31.

9.

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage.

Stork CT, Bocek M, Crossley MP, Sollier J, Sanz LA, Chédin F, Swigut T, Cimprich KA.

Elife. 2016 Aug 23;5. pii: e17548. doi: 10.7554/eLife.17548.

10.

DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome.

Slaats GG, Saldivar JC, Bacal J, Zeman MK, Kile AC, Hynes AM, Srivastava S, Nazmutdinova J, den Ouden K, Zagers MS, Foletto V, Verhaar MC, Miles C, Sayer JA, Cimprich KA, Giles RH.

J Clin Invest. 2015 Sep;125(9):3657-66. doi: 10.1172/JCI80657. Epub 2015 Aug 24.

11.

HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.

Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA.

Mol Cell. 2015 Jun 18;58(6):1090-100. doi: 10.1016/j.molcel.2015.05.013. Epub 2015 Jun 4.

12.

Breaking bad: R-loops and genome integrity.

Sollier J, Cimprich KA.

Trends Cell Biol. 2015 Sep;25(9):514-22. doi: 10.1016/j.tcb.2015.05.003. Epub 2015 Jun 1. Review.

13.

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.

Sollier J, Stork CT, García-Rubio ML, Paulsen RD, Aguilera A, Cimprich KA.

Mol Cell. 2014 Dec 18;56(6):777-85. doi: 10.1016/j.molcel.2014.10.020. Epub 2014 Nov 26.

14.

DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.

Zeman MK, Lin JR, Freire R, Cimprich KA.

J Cell Biol. 2014 Jul 21;206(2):183-97. doi: 10.1083/jcb.201311063. Epub 2014 Jul 14.

15.

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.

Hamperl S, Cimprich KA.

DNA Repair (Amst). 2014 Jul;19:84-94. doi: 10.1016/j.dnarep.2014.03.023. Epub 2014 Apr 18. Review.

16.

Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension.

de Jesus Perez VA, Yuan K, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L Jr, Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT.

Am J Respir Crit Care Med. 2014 May 15;189(10):1260-72. doi: 10.1164/rccm.201310-1749OC.

17.

Causes and consequences of replication stress.

Zeman MK, Cimprich KA.

Nat Cell Biol. 2014 Jan;16(1):2-9. doi: 10.1038/ncb2897. Review.

18.

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.

Mol Cell. 2013 Aug 22;51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.

19.

PHD domain from human SHPRH.

Machado LE, Pustovalova Y, Kile AC, Pozhidaeva A, Cimprich KA, Almeida FC, Bezsonova I, Korzhnev DM.

J Biomol NMR. 2013 Aug;56(4):393-9. doi: 10.1007/s10858-013-9758-2. Epub 2013 Aug 2. No abstract available.

20.

ATR phosphorylates SMARCAL1 to prevent replication fork collapse.

Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D.

Genes Dev. 2013 Jul 15;27(14):1610-23. doi: 10.1101/gad.214080.113.

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