Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 156


Claudin-2 suppresses GEF-H1, RHOA, and MRTF thereby impacting proliferation and profibrotic phenotype of tubular cells.

Dan Q, Shi Y, Rabani R, Venugopal S, Xiao J, Anwer S, Ding M, Speight P, Pan W, Alexander RT, Kapus A, Szászi K.

J Biol Chem. 2019 Sep 3. pii: jbc.RA118.006484. doi: 10.1074/jbc.RA118.006484. [Epub ahead of print]


The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1.

Demian WL, Persaud A, Jiang C, Coyaud É, Liu S, Kapus A, Kafri R, Raught B, Rotin D.

Cell Rep. 2019 May 7;27(6):1886-1896.e6. doi: 10.1016/j.celrep.2019.04.034.


Profibrotic epithelial phenotype: a central role for MRTF and TAZ.

Bialik JF, Ding M, Speight P, Dan Q, Miranda MZ, Di Ciano-Oliveira C, Kofler MM, Rotstein OD, Pedersen SF, Szászi K, Kapus A.

Sci Rep. 2019 Mar 13;9(1):4323. doi: 10.1038/s41598-019-40764-7.


Mediated nuclear import and export of TAZ and the underlying molecular requirements.

Kofler M, Speight P, Little D, Di Ciano-Oliveira C, Szászi K, Kapus A.

Nat Commun. 2018 Nov 23;9(1):4966. doi: 10.1038/s41467-018-07450-0.


Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock.

Leung CH, Caldarone CA, Guan R, Wen XY, Ailenberg M, Kapus A, Szaszi K, Rotstein OD.

Antioxid Redox Signal. 2019 May 10;30(14):1760-1773. doi: 10.1089/ars.2018.7541. Epub 2018 Dec 20.


Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance.

Lichner Z, Saleeb R, Butz H, Ding Q, Nofech-Mozes R, Riad S, Farag M, Varkouhi AK, Dos Santos CC, Kapus A, Yousef GM.

FASEB J. 2019 Jan;33(1):1347-1359. doi: 10.1096/fj.201800596R. Epub 2018 Aug 27.


Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment.

Chen Z, Kapus A, Khatri I, Kos O, Zhu F, Gorczynski RM.

Leuk Res. 2018 Jun;69:72-80. doi: 10.1016/j.leukres.2018.04.007. Epub 2018 Apr 19.


Hemorrhagic Shock/Resuscitation Reduces the M2 Phenotype of Alveolar Macrophages: A Potential Mechanism Contributing to Increased LPS-Induced Lung Injury.

Safavian D, Leung CH, Kapus A, Ailenberg M, Szaszi K, Shani R, Di Ciano-Oliveira C, Ghazarian M, Rotstein O.

Shock. 2019 Feb;51(2):213-220. doi: 10.1097/SHK.0000000000001135.


Should basic science matter to clinicians?

Filewod NC, Batt J, Kapus A, Szaszi K, Fairn GD, Slutsky AS, Lee WL.

Lancet. 2018 Feb 3;391(10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. No abstract available.


Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac.

Amoozadeh Y, Anwer S, Dan Q, Venugopal S, Shi Y, Branchard E, Liedtke E, Ailenberg M, Rotstein OD, Kapus A, Szászi K.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C366-C378. doi: 10.1152/ajpcell.00234.2017. Epub 2017 Nov 29.


Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition.

Zabini D, Granton E, Hu Y, Miranda MZ, Weichelt U, Breuils Bonnet S, Bonnet S, Morrell NW, Connelly KA, Provencher S, Ghanim B, Klepetko W, Olschewski A, Kapus A, Kuebler WM.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):244-260. doi: 10.1164/rccm.201702-0386OC. Erratum in: Am J Respir Crit Care Med. 2019 Apr 1;199(7):932.


TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism.

Miranda MZ, Bialik JF, Speight P, Dan Q, Yeung T, Szászi K, Pedersen SF, Kapus A.

J Biol Chem. 2017 Sep 8;292(36):14902-14920. doi: 10.1074/jbc.M117.780502. Epub 2017 Jul 24.


Role of integrins in mediating cardiac fibroblast-cardiomyocyte cross talk: a dynamic relationship in cardiac biology and pathophysiology.

Civitarese RA, Kapus A, McCulloch CA, Connelly KA.

Basic Res Cardiol. 2017 Jan;112(1):6. doi: 10.1007/s00395-016-0598-6. Epub 2016 Dec 20. Review.


Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.

Zhang Y, Connelly KA, Thai K, Wu X, Kapus A, Kepecs D, Gilbert RE.

Am J Pathol. 2017 Jan;187(1):80-90. doi: 10.1016/j.ajpath.2016.09.016.


Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migration.

Moodley S, Derouet M, Bai XH, Xu F, Kapus A, Yang BB, Liu M.

Oncotarget. 2016 Nov 22;7(47):76437-76452. doi: 10.18632/oncotarget.13261.


MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.

Li CX, Talele NP, Boo S, Koehler A, Knee-Walden E, Balestrini JL, Speight P, Kapus A, Hinz B.

Nat Mater. 2017 Mar;16(3):379-389. doi: 10.1038/nmat4780. Epub 2016 Oct 31.


Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.

Goldenberg NM, Steinberg BE, Rutka JT, Chen R, Cabral V, Rosenblum ND, Kapus A, Lee WL.

CMAJ Open. 2016 Aug 22;4(3):E444-E447. eCollection 2016 Jul-Sep.


The α11 integrin mediates fibroblast-extracellular matrix-cardiomyocyte interactions in health and disease.

Civitarese RA, Talior-Volodarsky I, Desjardins JF, Kabir G, Switzer J, Mitchell M, Kapus A, McCulloch CA, Gullberg D, Connelly KA.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H96-H106. doi: 10.1152/ajpheart.00918.2015. Epub 2016 May 13.


Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src.

Tsang JL, Jia SH, Parodo J, Plant P, Lodyga M, Charbonney E, Szaszi K, Kapus A, Marshall JC.

PLoS One. 2016 Apr 21;11(4):e0153946. doi: 10.1371/journal.pone.0153946. eCollection 2016.

Supplemental Content

Support Center