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Items: 1 to 20 of 98


Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease.

Palanimuthu D, Wu Z, Jansson PJ, Braidy N, Bernhardt PV, Richardson DR, Kalinowski DS.

Dalton Trans. 2018 May 29;47(21):7190-7205. doi: 10.1039/c8dt01099d.


Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

Park KC, Menezes SV, Kalinowski DS, Sahni S, Jansson PJ, Kovacevic Z, Richardson DR.

Biochim Biophys Acta Mol Basis Dis. 2018 Aug;1864(8):2644-2663. doi: 10.1016/j.bbadis.2018.04.011. Epub 2018 Apr 19.


A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.

Palanimuthu D, Poon R, Sahni S, Anjum R, Hibbs D, Lin HY, Bernhardt PV, Kalinowski DS, Richardson DR.

Eur J Med Chem. 2017 Oct 20;139:612-632. doi: 10.1016/j.ejmech.2017.08.021. Epub 2017 Aug 9.


Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia.

Chiang S, Kalinowski DS, Jansson PJ, Richardson DR, Huang ML.

Neurochem Int. 2018 Jul;117:35-48. doi: 10.1016/j.neuint.2017.08.002. Epub 2017 Aug 4. Review.


Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

Merlot AM, Kalinowski DS, Kovacevic Z, Jansson PJ, Sahni S, Huang ML, Lane DL, Lok H, Richardson DR.

Curr Med Chem. 2017 Jul 5. doi: 10.2174/0929867324666170705120809. [Epub ahead of print]


Novel Thiosemicarbazones Inhibit Lysine-Rich Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) Coisolated (LYRIC) and the LYRIC-Induced Epithelial-Mesenchymal Transition via Upregulation of N-Myc Downstream-Regulated Gene 1 (NDRG1).

Xi R, Pun IH, Menezes SV, Fouani L, Kalinowski DS, Huang ML, Zhang X, Richardson DR, Kovacevic Z.

Mol Pharmacol. 2017 May;91(5):499-517. doi: 10.1124/mol.116.107870. Epub 2017 Mar 8.


Letter to the Editor: "Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques".

Merlot AM, Sahni S, Lane DJ, Richardson V, Huang ML, Kalinowski DS, Richardson DR.

Int J Mol Sci. 2016 Nov 16;17(11). pii: E1916.


Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.

Stacy AE, Palanimuthu D, Bernhardt PV, Kalinowski DS, Jansson PJ, Richardson DR.

J Med Chem. 2016 Sep 22;59(18):8601-20. doi: 10.1021/acs.jmedchem.6b01050. Epub 2016 Aug 30.


Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.

Yingchoncharoen P, Kalinowski DS, Richardson DR.

Pharmacol Rev. 2016 Jul;68(3):701-87. doi: 10.1124/pr.115.012070. Review.


Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

Park KC, Fouani L, Jansson PJ, Wooi D, Sahni S, Lane DJ, Palanimuthu D, Lok HC, Kovačević Z, Huang ML, Kalinowski DS, Richardson DR.

Metallomics. 2016 Sep 1;8(9):874-86. doi: 10.1039/c6mt00105j. Epub 2016 Jun 23. Review.


Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

Sahni S, Kovacevic Z, Kalinowski DS, Huang M, Menezes S, Krishan S, Lane DJ, Jansson PJ, Richardson DR.

Future Med Chem. 2016 May;8(7):727-9. doi: 10.4155/fmc-2016-0066. Epub 2016 May 5. No abstract available.


Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia.

Chiang S, Kovacevic Z, Sahni S, Lane DJ, Merlot AM, Kalinowski DS, Huang ML, Richardson DR.

Clin Sci (Lond). 2016 Jun 1;130(11):853-70. doi: 10.1042/CS20160072. Review.


Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

Gutierrez EM, Seebacher NA, Arzuman L, Kovacevic Z, Lane DJ, Richardson V, Merlot AM, Lok H, Kalinowski DS, Sahni S, Jansson PJ, Richardson DR.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1665-81. doi: 10.1016/j.bbamcr.2016.04.017. Epub 2016 Apr 19.


Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

Merlot AM, Shafie NH, Yu Y, Richardson V, Jansson PJ, Sahni S, Lane DJR, Kovacevic Z, Kalinowski DS, Richardson DR.

Biochem Pharmacol. 2016 Jun 1;109:27-47. doi: 10.1016/j.bcp.2016.04.001. Epub 2016 Apr 6.


Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.

Stacy AE, Palanimuthu D, Bernhardt PV, Kalinowski DS, Jansson PJ, Richardson DR.

J Med Chem. 2016 May 26;59(10):4965-84. doi: 10.1021/acs.jmedchem.6b00238. Epub 2016 Apr 26.


Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.

Paluncic J, Kovacevic Z, Jansson PJ, Kalinowski D, Merlot AM, Huang ML, Lok HC, Sahni S, Lane DJ, Richardson DR.

Biochim Biophys Acta. 2016 Apr;1863(4):770-84. doi: 10.1016/j.bbamcr.2016.01.025. Epub 2016 Feb 1. Review.


Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR.

Biochim Biophys Acta. 2016 Apr;1863(4):727-48. doi: 10.1016/j.bbamcr.2016.01.026. Epub 2016 Feb 2. Review.


Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.

Al-Eisawi Z, Stefani C, Jansson PJ, Arvind A, Sharpe PC, Basha MT, Iskander GM, Kumar N, Kovacevic Z, Lane DJ, Sahni S, Bernhardt PV, Richardson DR, Kalinowski DS.

J Med Chem. 2016 Jan 14;59(1):294-312. doi: 10.1021/acs.jmedchem.5b01399. Epub 2015 Dec 31.


Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.

Sestak V, Stariat J, Cermanova J, Potuckova E, Chladek J, Roh J, Bures J, Jansova H, Prusa P, Sterba M, Micuda S, Simunek T, Kalinowski DS, Richardson DR, Kovarikova P.

Oncotarget. 2015 Dec 15;6(40):42411-28. doi: 10.18632/oncotarget.6389.

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