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Items: 20


Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum.

Bancells C, Llorà-Batlle O, Poran A, Nötzel C, Rovira-Graells N, Elemento O, Kafsack BFC, Cortés A.

Nat Microbiol. 2018 Nov 26. doi: 10.1038/s41564-018-0291-7. [Epub ahead of print]


Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.


Single-Cell Transcriptome Profiling of Protozoan and Metazoan Parasites.

Nötzel C, Poran A, Kafsack BFC.

Trends Parasitol. 2018 Sep;34(9):731-734. doi: 10.1016/ Epub 2018 May 26.


Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.

Poran A, Nötzel C, Aly O, Mencia-Trinchant N, Harris CT, Guzman ML, Hassane DC, Elemento O, Kafsack BFC.

Nature. 2017 Nov 2;551(7678):95-99. doi: 10.1038/nature24280. Epub 2017 Sep 25.


A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion.

Coleman BI, Skillman KM, Jiang RHY, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BFC, Marti M, Llinás M, Buckee CO, Duraisingh MT.

Cell Host Microbe. 2014 Aug 13;16(2):177-186. doi: 10.1016/j.chom.2014.06.014.


A transcriptional switch underlies commitment to sexual development in malaria parasites.

Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA, Cortés A, Llinás M.

Nature. 2014 Mar 13;507(7491):248-52. doi: 10.1038/nature12920. Epub 2014 Feb 23.


A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium.

Sinha A, Hughes KR, Modrzynska KK, Otto TD, Pfander C, Dickens NJ, Religa AA, Bushell E, Graham AL, Cameron R, Kafsack BFC, Williams AE, Llinas M, Berriman M, Billker O, Waters AP.

Nature. 2014 Mar 13;507(7491):253-257. doi: 10.1038/nature12970. Epub 2014 Feb 23.


Stress and sex in malaria parasites: Why does commitment vary?

Carter LM, Kafsack BF, Llinás M, Mideo N, Pollitt LC, Reece SE.

Evol Med Public Health. 2013 Jan;2013(1):135-47. doi: 10.1093/emph/eot011. Epub 2013 Jun 4.


Whole-genome analysis of Plasmodium spp. Utilizing a new agilent technologies DNA microarray platform.

Painter HJ, Altenhofen LM, Kafsack BF, Llinás M.

Methods Mol Biol. 2013;923:213-9.


Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites.

Lagal V, Binder EM, Huynh MH, Kafsack BF, Harris PK, Diez R, Chen D, Cole RN, Carruthers VB, Kim K.

Cell Microbiol. 2010 Dec;12(12):1792-808. doi: 10.1111/j.1462-5822.2010.01509.x.


Apicomplexan perforin-like proteins.

Kafsack BF, Carruthers VB.

Commun Integr Biol. 2010 Jan;3(1):18-23.


Eating at the table of another: metabolomics of host-parasite interactions.

Kafsack BF, Llinás M.

Cell Host Microbe. 2010 Feb 18;7(2):90-9. doi: 10.1016/j.chom.2010.01.008. Review.


Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.

Kafsack BF, Pena JD, Coppens I, Ravindran S, Boothroyd JC, Carruthers VB.

Science. 2009 Jan 23;323(5913):530-3. doi: 10.1126/science.1165740. Epub 2008 Dec 18.


Kinetic modeling of Toxoplasma gondii invasion.

Kafsack BF, Carruthers VB, Pineda FJ.

J Theor Biol. 2007 Dec 21;249(4):817-25. Epub 2007 Sep 14.


The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins.

Zhou XW, Kafsack BF, Cole RN, Beckett P, Shen RF, Carruthers VB.

J Biol Chem. 2005 Oct 7;280(40):34233-44. Epub 2005 Jul 7.


Synchronous invasion of host cells by Toxoplasma gondii.

Kafsack BF, Beckers C, Carruthers VB.

Mol Biochem Parasitol. 2004 Aug;136(2):309-11. No abstract available.


The novel coccidian micronemal protein MIC11 undergoes proteolytic maturation by sequential cleavage to remove an internal propeptide.

Harper JM, Zhou XW, Pszenny V, Kafsack BF, Carruthers VB.

Int J Parasitol. 2004 Aug;34(9):1047-58.


Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase.

Rasoloson D, Shi L, Chong CR, Kafsack BF, Sullivan DJ.

Biochem J. 2004 Aug 1;381(Pt 3):803-11.


Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.

Seamons A, Sutton J, Bai D, Baird E, Bonn N, Kafsack BF, Shabanowitz J, Hunt DF, Beeson C, Goverman J.

J Exp Med. 2003 May 19;197(10):1391-7.

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