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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1979 1
1981 2
1983 1
1984 1
1985 3
1987 1
1988 4
1989 4
1990 2
1991 1
1992 2
1993 1
1994 1
1995 6
1996 2
1997 7
1998 12
1999 12
2000 7
2001 13
2002 23
2003 20
2004 21
2005 21
2006 23
2007 18
2008 30
2009 25
2010 25
2011 44
2012 50
2013 59
2014 40
2015 63
2016 53
2017 56
2018 50
2019 62
2020 69
2021 88
2022 101
2023 105
2024 47

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1,066 results

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Page 1
KSR as a therapeutic target for Ras-dependent cancers.
Neilsen BK, Frodyma DE, Lewis RE, Fisher KW. Neilsen BK, et al. Expert Opin Ther Targets. 2017 May;21(5):499-509. doi: 10.1080/14728222.2017.1311325. Epub 2017 Apr 7. Expert Opin Ther Targets. 2017. PMID: 28333549 Free PMC article. Review.
We then focus on the most recent literature that describes the crystal structure of the kinase domain of KSR2 in complex with MEK1, KSR-RAF dimerization particularly in response to RAF inhibition, and novel attempts to target KSR proteins directly. ...Recent advance …
We then focus on the most recent literature that describes the crystal structure of the kinase domain of KSR2 in complex with MEK1, KSR …
Structural basis for the action of the drug trametinib at KSR-bound MEK.
Khan ZM, Real AM, Marsiglia WM, Chow A, Duffy ME, Yerabolu JR, Scopton AP, Dar AC. Khan ZM, et al. Nature. 2020 Dec;588(7838):509-514. doi: 10.1038/s41586-020-2760-4. Epub 2020 Sep 14. Nature. 2020. PMID: 32927473 Free PMC article.
Here we report X-ray crystal structures of MEK bound to the scaffold KSR (kinase suppressor of RAS) with various MEK inhibitors, including the clinical drug trametinib. The structures reveal an unexpected mode of binding in which trametinib directly engages KSR at t …
Here we report X-ray crystal structures of MEK bound to the scaffold KSR (kinase suppressor of RAS) with various MEK inhibitors, incl …
KSR/KSTR Guidelines for the Use of Diagnostic Imaging for COVID-19.
Jin KN, Yoon SH, Park CH, Beck KS, Do KH, Yong HS. Jin KN, et al. Taehan Yongsang Uihakhoe Chi. 2020 May;81(3):577-582. doi: 10.3348/jksr.2020.81.3.577. Epub 2020 Apr 21. Taehan Yongsang Uihakhoe Chi. 2020. PMID: 36238630 Free PMC article. Review.
KSR: a MAPK scaffold of the Ras pathway?
Morrison DK. Morrison DK. J Cell Sci. 2001 May;114(Pt 9):1609-12. doi: 10.1242/jcs.114.9.1609. J Cell Sci. 2001. PMID: 11309192 Review.
However, in the six years since its discovery, KSR has been found to lack several key properties of known protein kinases, which has cast doubt on whether KSR is indeed a functional enzyme. A major breakthrough in our understanding of the role of KSR in signa …
However, in the six years since its discovery, KSR has been found to lack several key properties of known protein kinases, which has …
KSR induces RAS-independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors.
Paniagua G, Jacob HKC, Brehey O, García-Alonso S, Lechuga CG, Pons T, Musteanu M, Guerra C, Drosten M, Barbacid M. Paniagua G, et al. Mol Oncol. 2022 Sep;16(17):3066-3081. doi: 10.1002/1878-0261.13213. Epub 2022 Apr 12. Mol Oncol. 2022. PMID: 35313064 Free PMC article.
Here, we demonstrate that ectopic expression of KSR1 or KSR2 is sufficient to activate the MAPK pathway and to induce cell proliferation in the absence of RAS proteins. In contrast, the ectopic expression of KSR proteins is not sufficient to induce cell proliferation in th …
Here, we demonstrate that ectopic expression of KSR1 or KSR2 is sufficient to activate the MAPK pathway and to induce cell proliferation in …
KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
Clapéron A, Therrien M. Clapéron A, et al. Oncogene. 2007 May 14;26(22):3143-58. doi: 10.1038/sj.onc.1210408. Oncogene. 2007. PMID: 17496912 Review.
Here, through the angle of studies conducted in Drosophila and C. elegans, we present two such proteins, the kinase suppressor of RAS (KSR) and connector enhancer of KSR (CNK) scaffolds, and highlight their implication in a novel mechanism regulating RAS-mediated RA …
Here, through the angle of studies conducted in Drosophila and C. elegans, we present two such proteins, the kinase suppressor of RAS (KS …
KSR--a regulator and scaffold protein of the MAPK pathway.
Raabe T, Rapp UR. Raabe T, et al. Sci STKE. 2002 Jun 11;2002(136):pe28. doi: 10.1126/stke.2002.136.pe28. Sci STKE. 2002. PMID: 12060787 Review.
Raabe and Rapp discuss how the scaffolding proteins may spatially localize mitogen-activated protein kinase (MAPK) signaling cassettes to allow signaling specificity. They focus on the adaptor kinase suppressor of Ras (KSR) and describe how the interactions between KSR …
Raabe and Rapp discuss how the scaffolding proteins may spatially localize mitogen-activated protein kinase (MAPK) signaling cassettes to al …
Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.
Marsiglia WM, Chow A, Khan ZM, He L, Dar AC. Marsiglia WM, et al. Nat Chem Biol. 2024 Mar;20(3):373-381. doi: 10.1038/s41589-023-01454-8. Epub 2023 Nov 2. Nat Chem Biol. 2024. PMID: 37919548 Free PMC article.
The RAS-mitogen-activated protein kinase (MAPK) pathway includes KSR, RAF, MEK and the phospho-regulatory sensor 14-3-3. Specific assemblies among these components drive various diseases and likely dictate efficacy for numerous targeted therapies, including allosteric MEK …
The RAS-mitogen-activated protein kinase (MAPK) pathway includes KSR, RAF, MEK and the phospho-regulatory sensor 14-3-3. Specific ass …
KSR: a novel player in the RAS pathway.
Downward J. Downward J. Cell. 1995 Dec 15;83(6):831-4. doi: 10.1016/0092-8674(95)90198-1. Cell. 1995. PMID: 8521506 Free article. Review. No abstract available.
1,066 results