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Behav Brain Res. 2015 Feb 1;278:559-62. doi: 10.1016/j.bbr.2014.09.047. Epub 2014 Oct 7.

Juvenile stress alters LTP in ventral hippocampal slices: involvement of noradrenergic mechanisms.

Author information

1
Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel. Electronic address: gaygrig2002@gmail.com.
2
Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: zivardi@gmail.com.
3
Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: albrechtannedr@gmail.com.
4
Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel; Psychology Department, University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: galrichterlevin@gmail.com.
5
Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel. Electronic address: menahem.segal@weizmann.ac.il.

Abstract

Childhood adversity is a prominent risk factor for developing stress-related disorders in adulthood. It can be modeled in rodents, where altered stress responses in adulthood have been observed. The ventral hippocampus is thought to be involved in emotional responses and displays a unique modulation of synaptic plasticity following exposure to stress. Here, we investigated the long-term effect of juvenile stress (at postnatal age of 27-29 days) on synaptic plasticity in the ventral and dorsal hippocampus of adult, 3 month old rats. The rats that had experienced juvenile stress expressed impaired LTP in the dorsal hippocampus (DH), while ventral hippocampus (VH) LTP was facilitated. Furthermore, juvenile stress caused reduced sensitivity to the beta-adrenergic agonist isoproterenol (Iso; 1 μM) in the adult DH, while it enhanced its action in VH slices. Further, juvenile stress resulted in an increase in the expression of beta1-adrenergic receptors in the VH but not in the DH, as revealed by western blot. Taken together, the ventral hippocampus expresses a lasting sensitivity to adrenergic modulation, thus likely to affect the emotional response to challenging situations in adulthood.

KEYWORDS:

Corticosterone; Dorsal and ventral hippocampus; Juvenile stress; LTP; Norepinephrine

PMID:
25300466
DOI:
10.1016/j.bbr.2014.09.047
[Indexed for MEDLINE]

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