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Items: 14

1.

Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis.

Hu Z, Wang Y, Huang F, Chen R, Li C, Wang F, Goto J, Kwiatkowski DJ, Wdzieczak-Bakala J, Tu P, Liu J, Zha X, Zhang H.

J Biol Chem. 2015 Oct 16;290(42):25756-65. doi: 10.1074/jbc.M115.665208. Epub 2015 Aug 20.

2.

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model.

Prabhakar S, Zhang X, Goto J, Han S, Lai C, Bronson R, Sena-Esteves M, Ramesh V, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.

Neurobiol Dis. 2015 Oct;82:22-31. doi: 10.1016/j.nbd.2015.04.018. Epub 2015 May 24.

3.

Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.

Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M.

Hum Mol Genet. 2014 Jul 15;23(14):3865-74. doi: 10.1093/hmg/ddu101. Epub 2014 Mar 5.

4.

Stochastic model of Tsc1 lesions in mouse brain.

Prabhakar S, Goto J, Zhang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.

PLoS One. 2013 May 16;8(5):e64224. doi: 10.1371/journal.pone.0064224. Print 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/6a5b0a50-27e4-49bc-b82a-9267dd63af53. Zuang, Xuan [corrected to Zhang, Xuan].

5.

Prenatal rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice.

Tsai PT, Greene-Colozzi E, Goto J, Anderl S, Kwiatkowski DJ, Sahin M.

Behav Genet. 2013 Jan;43(1):51-9. doi: 10.1007/s10519-012-9571-9. Epub 2012 Dec 12.

6.

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.

Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1070-9. doi: 10.1073/pnas.1106454108. Epub 2011 Oct 24.

7.

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.

Anderl S, Freeland M, Kwiatkowski DJ, Goto J.

Hum Mol Genet. 2011 Dec 1;20(23):4597-604. doi: 10.1093/hmg/ddr393. Epub 2011 Sep 1.

8.

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.

Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4129-34. doi: 10.1073/pnas.1014769108. Epub 2011 Feb 15.

9.

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.

Malhowski AJ, Hira H, Bashiruddin S, Warburton R, Goto J, Robert B, Kwiatkowski DJ, Finlay GA.

Hum Mol Genet. 2011 Apr 1;20(7):1290-305. doi: 10.1093/hmg/ddq570. Epub 2011 Jan 6.

10.

A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.

Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ.

Hum Mol Genet. 2009 Jul 1;18(13):2378-87. doi: 10.1093/hmg/ddp176. Epub 2009 Apr 8.

11.

Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.

Goto J, Tezuka T, Nakazawa T, Sagara H, Yamamoto T.

Mol Cell Neurosci. 2008 Jun;38(2):203-12. doi: 10.1016/j.mcn.2008.02.009. Epub 2008 Mar 4.

PMID:
18403215
12.

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.

Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T.

EMBO J. 2006 Jun 21;25(12):2867-77. Epub 2006 May 18.

13.

Altered gene expression in the adult brain of fyn-deficient mice.

Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T.

Cell Mol Neurobiol. 2004 Feb;24(1):149-59.

PMID:
15049519
14.

Essential hydrophilic carboxyl-terminal regions including cysteine residues of the yeast stretch-activated calcium-permeable channel Mid1.

Maruoka T, Nagasoe Y, Inoue S, Mori Y, Goto J, Ikeda M, Iida H.

J Biol Chem. 2002 Apr 5;277(14):11645-52. Epub 2002 Jan 16.

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