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J Neuroimmunol. 2007 Dec;192(1-2):134-44. Epub 2007 Nov 8.

Immunological properties of human embryonic stem cell-derived oligodendrocyte progenitor cells.

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Geron Corporation, Menlo Park, California, USA.


A major concern in the use of allotransplantation of human embryonic stem cell (hESC)-based therapies is the possibility of allogeneic rejection by the host's immune system. In this report, we determined the immunological properties of hESC-derived oligodendrocyte progenitor cells (OPC) that have the potential for clinical application for the treatment of patients with spinal cord injury. In vitro immunological studies suggest that hESC-derived OPCs are poor targets for both the innate and the adaptive human immune effector cells as well as resistant to lysis by anti-Neu5Gc antibodies. These results indicate that hESC-derived OPCs retain some of the unique immunological properties of the parental cell line from which they were differentiated.

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