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J Chromatogr A. 1997 Feb 21;762(1-2):219-25.

Refractive-index detection by interferometric backscatter in packed-capillary high-performance liquid chromatography.

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Department of Chemistry and Biochemistry, Texas Tech University, Lubbock 79409-1061, USA.


A simple, inexpensive, micro-volume refractive index detector has been applied to packed capillary high-performance liquid chromatography. Nanoliter detector volumes produced by a unique optical train, based on interferometric backscatter, allows for universal solute detection at the picogram level. System utility is demonstrated by reversed-phase separation of a test mixture containing ppm levels of NaCl, phenol, ethyl benzene and toluene.

[Indexed for MEDLINE]

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