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Items: 1 to 20 of 36


A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.

Nonaka T, Yamada T, Ishimura T, Zuo D, Moffett JR, Neale JH, Yamamoto T.

Mol Pain. 2017 Jan;13:1744806917697008. doi: 10.1177/1744806917697008.


NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.

Olszewski RT, Janczura KJ, Bzdega T, Der EK, Venzor F, O'Rourke B, Hark TJ, Craddock KE, Balasubramanian S, Moussa C, Neale JH.

Neurochem Res. 2017 Sep;42(9):2646-2657. doi: 10.1007/s11064-017-2181-4. Epub 2017 Mar 11.


Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury.

Cao Y, Gao Y, Xu S, Bao J, Lin Y, Luo X, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C.

BMC Neurosci. 2016 Apr 18;17:15. doi: 10.1186/s12868-016-0251-1.


Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injury.

Gao Y, Xu S, Cui Z, Zhang M, Lin Y, Cai L, Wang Z, Luo X, Zheng Y, Wang Y, Luo Q, Jiang J, Neale JH, Zhong C.

J Neurochem. 2015 Jul;134(2):340-53. doi: 10.1111/jnc.13123. Epub 2015 Apr 28.


Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.

Wenqiang C, Lonskaya I, Hebron ML, Ibrahim Z, Olszewski RT, Neale JH, Moussa CE.

Hum Mol Genet. 2014 Sep 15;23(18):4960-9. doi: 10.1093/hmg/ddu211. Epub 2014 May 8.


NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test.

Janczura KJ, Olszewski RT, Bzdega T, Bacich DJ, Heston WD, Neale JH.

Eur J Pharmacol. 2013 Feb 15;701(1-3):27-32. doi: 10.1016/j.ejphar.2012.11.027. Epub 2012 Nov 29.


Immunohistological and electrophysiological evidence that N-acetylaspartylglutamate is a co-transmitter at the vertebrate neuromuscular junction.

Walder KK, Ryan SB, Bzdega T, Olszewski RT, Neale JH, Lindgren CA.

Eur J Neurosci. 2013 Jan;37(1):118-29. doi: 10.1111/ejn.12027. Epub 2012 Nov 8.


NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation.

Yamada T, Zuo D, Yamamoto T, Olszewski RT, Bzdega T, Moffett JR, Neale JH.

Mol Pain. 2012 Sep 12;8:67. doi: 10.1186/1744-8069-8-67.


Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.

Zuo D, Bzdega T, Olszewski RT, Moffett JR, Neale JH.

J Biol Chem. 2012 Jun 22;287(26):21773-82. doi: 10.1074/jbc.M112.363226. Epub 2012 May 8.


mGluR3 and not mGluR2 receptors mediate the efficacy of NAAG peptidase inhibitor in validated model of schizophrenia.

Olszewski RT, Bzdega T, Neale JH.

Schizophr Res. 2012 Apr;136(1-3):160-1. doi: 10.1016/j.schres.2012.01.007. Epub 2012 Feb 1. No abstract available.


N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitro.

Neale JH.

J Neurochem. 2011 Dec;119(5):891-5. doi: 10.1111/j.1471-4159.2011.07380.x. No abstract available.


Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide family.

Neale JH, Olszewski RT, Zuo D, Janczura KJ, Profaci CP, Lavin KM, Madore JC, Bzdega T.

J Neurochem. 2011 Aug;118(4):490-8. doi: 10.1111/j.1471-4159.2011.07338.x. Epub 2011 Jul 1. Review.


Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI.

Feng JF, Van KC, Gurkoff GG, Kopriva C, Olszewski RT, Song M, Sun S, Xu M, Neale JH, Yuen PW, Lowe DA, Zhou J, Lyeth BG.

Brain Res. 2011 Jun 13;1395:62-73. doi: 10.1016/j.brainres.2011.04.022. Epub 2011 Apr 20.


Effective collaborations: how to protect yourself, your collaborators, and your data.

Kozikowski AP, Neale JH.

ChemMedChem. 2011 Mar 7;6(3):411-4. doi: 10.1002/cmdc.201000529. Epub 2011 Jan 27. No abstract available.


Group II mGluR agonist LY354740 and NAAG peptidase inhibitor effects on prepulse inhibition in PCP and D-amphetamine models of schizophrenia.

Profaci CP, Krolikowski KA, Olszewski RT, Neale JH.

Psychopharmacology (Berl). 2011 Jul;216(2):235-43. doi: 10.1007/s00213-011-2200-0. Epub 2011 Feb 16.


Type 2 metabotropic glutamate receptor (mGluR2) fails to negatively couple to cGMP in stably transfected cells.

Wroblewska B, Wegorzewska IN, Bzdega T, Neale JH.

Neurochem Int. 2011 Feb;58(2):176-9. doi: 10.1016/j.neuint.2010.11.012. Epub 2010 Nov 27.


Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain.

Yamamoto T, Kozikowski A, Zhou J, Neale JH.

Mol Pain. 2008 Aug 1;4:31. doi: 10.1186/1744-8069-4-31.


Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors.

Olszewski RT, Wegorzewska MM, Monteiro AC, Krolikowski KA, Zhou J, Kozikowski AP, Long K, Mastropaolo J, Deutsch SI, Neale JH.

Biol Psychiatry. 2008 Jan 1;63(1):86-91. Epub 2007 Jun 27.


Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats.

Yamamoto T, Saito O, Aoe T, Bartolozzi A, Sarva J, Zhou J, Kozikowski A, Wroblewska B, Bzdega T, Neale JH.

Eur J Neurosci. 2007 Jan;25(1):147-58.


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