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Items: 7


IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms.

Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, Moyes DL.

J Immunol. 2018 Jul 15;201(2):627-634. doi: 10.4049/jimmunol.1800515. Epub 2018 Jun 11.


Detection of IL-36γ through noninvasive tape stripping reliably discriminates psoriasis from atopic eczema.

Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, Goodfield M, Wright A, Helliwell P, Edward S, Brown GD, Reid DM, Wenzel J, Stacey M, Wittmann M.

J Allergy Clin Immunol. 2018 Sep;142(3):988-991.e4. doi: 10.1016/j.jaci.2018.04.031. Epub 2018 May 18. No abstract available.


Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ.

Ainscough JS, Macleod T, McGonagle D, Brakefield R, Baron JM, Alase A, Wittmann M, Stacey M.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2748-E2757. doi: 10.1073/pnas.1620954114. Epub 2017 Mar 13.


Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin.

Ainscough JS, Gerberick GF, Kimber I, Dearman RJ.

J Biol Chem. 2015 Dec 25;290(52):31151-61. doi: 10.1074/jbc.M115.680694. Epub 2015 Nov 11.


P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Englezou PC, Rothwell SW, Ainscough JS, Brough D, Landsiedel R, Verkhratsky A, Kimber I, Dearman RJ.

Cytokine. 2015 Aug;74(2):293-304. doi: 10.1016/j.cyto.2015.05.013. Epub 2015 Jun 9.


Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

Ainscough JS, Frank Gerberick G, Zahedi-Nejad M, Lopez-Castejon G, Brough D, Kimber I, Dearman RJ.

J Biol Chem. 2014 Dec 19;289(51):35582-92. doi: 10.1074/jbc.M114.595686. Epub 2014 Nov 4.


Danger, intracellular signaling, and the orchestration of dendritic cell function in skin sensitization.

Ainscough JS, Frank Gerberick G, Dearman RJ, Kimber I.

J Immunotoxicol. 2013 Jul-Sep;10(3):223-34. doi: 10.3109/1547691X.2012.711782. Epub 2012 Sep 7. Review.


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