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Items: 1 to 20 of 33


Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

Stuart HT, Stirparo GG, Lohoff T, Bates LE, Kinoshita M, Lim CY, Sousa EJ, Maskalenka K, Radzisheuskaya A, Malcolm AA, Alves MRP, Lloyd RL, Nestorowa S, Humphreys P, Mansfield W, Reik W, Bertone P, Nichols J, Göttgens B, Silva JCR.

Cell Stem Cell. 2019 Sep 5;25(3):388-406.e8. doi: 10.1016/j.stem.2019.07.009. Epub 2019 Aug 15.


ZMYM2 inhibits NANOG-mediated reprogramming.

Lawrence M, Theunissen TW, Lombard P, Adams DJ, Silva JCR.

Wellcome Open Res. 2019 Jun 6;4:88. doi: 10.12688/wellcomeopenres.15250.1. eCollection 2019.


WDR5, BRCA1, and BARD1 Co-regulate the DNA Damage Response and Modulate the Mesenchymal-to-Epithelial Transition during Early Reprogramming.

Peñalosa-Ruiz G, Bousgouni V, Gerlach JP, Waarlo S, van de Ven JV, Veenstra TE, Silva JCR, van Heeringen SJ, Bakal C, Mulder KW, Veenstra GJC.

Stem Cell Reports. 2019 Apr 9;12(4):743-756. doi: 10.1016/j.stemcr.2019.02.006. Epub 2019 Mar 14.


Long-Term Perfusion Culture of Monoclonal Embryonic Stem Cells in 3D Hydrogel Beads for Continuous Optical Analysis of Differentiation.

Kleine-Brüggeney H, van Vliet LD, Mulas C, Gielen F, Agley CC, Silva JCR, Smith A, Chalut K, Hollfelder F.

Small. 2019 Feb;15(5):e1804576. doi: 10.1002/smll.201804576. Epub 2018 Dec 20.


Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males.

Sousa EJ, Stuart HT, Bates LE, Ghorbani M, Nichols J, Dietmann S, Silva JCR.

Cell Stem Cell. 2018 Jun 1;22(6):919-928.e6. doi: 10.1016/j.stem.2018.05.001. Epub 2018 May 24.


Reprogramming human cells to naïve pluripotency: how close are we?

Bates LE, Silva JC.

Curr Opin Genet Dev. 2017 Oct;46:58-65. doi: 10.1016/j.gde.2017.06.009. Epub 2017 Jun 29. Review.


One-step generation of conditional and reversible gene knockouts.

Andersson-Rolf A, Mustata RC, Merenda A, Kim J, Perera S, Grego T, Andrews K, Tremble K, Silva JC, Fink J, Skarnes WC, Koo BK.

Nat Methods. 2017 Mar;14(3):287-289. doi: 10.1038/nmeth.4156. Epub 2017 Jan 30.


Editorial overview: cell reprogramming, regeneration and repair.

Silva JC, Pera RA.

Curr Opin Genet Dev. 2014 Oct;28:v-vi. doi: 10.1016/j.gde.2014.11.003. Epub 2014 Nov 21. No abstract available.


MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner.

dos Santos RL, Tosti L, Radzisheuskaya A, Caballero IM, Kaji K, Hendrich B, Silva JC.

Cell Stem Cell. 2014 Jul 3;15(1):102-10. doi: 10.1016/j.stem.2014.04.019. Epub 2014 May 15. Erratum in: Cell Stem Cell. 2014 Sep 4;15(3):392.


Citrullination regulates pluripotency and histone H1 binding to chromatin.

Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T.

Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26.


NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.

Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC.

Curr Biol. 2014 Feb 3;24(3):340-6. doi: 10.1016/j.cub.2013.12.040. Epub 2014 Jan 23.


Nanog is dispensable for the generation of induced pluripotent stem cells.

Schwarz BA, Bar-Nur O, Silva JC, Hochedlinger K.

Curr Biol. 2014 Feb 3;24(3):347-50. doi: 10.1016/j.cub.2013.12.050. Epub 2014 Jan 23.


Do all roads lead to Oct4? the emerging concepts of induced pluripotency.

Radzisheuskaya A, Silva JC.

Trends Cell Biol. 2014 May;24(5):275-84. doi: 10.1016/j.tcb.2013.11.010. Epub 2013 Dec 23. Review.


A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.

Radzisheuskaya A, Chia Gle B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC.

Nat Cell Biol. 2013 Jun;15(6):579-90. doi: 10.1038/ncb2742. Epub 2013 Apr 30.


NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S, Levasseur DN, Li Z, Xu M, Reik W, Silva JC, Wang J.

Nature. 2013 Mar 21;495(7441):370-4. doi: 10.1038/nature11925. Epub 2013 Feb 10.


Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.

Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC.

J Cell Sci. 2012 Dec 15;125(Pt 24):6094-104. doi: 10.1242/jcs.113019. Epub 2012 Oct 17.


Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming.

Fidalgo M, Faiola F, Pereira CF, Ding J, Saunders A, Gingold J, Schaniel C, Lemischka IR, Silva JC, Wang J.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16202-7. doi: 10.1073/pnas.1208533109. Epub 2012 Sep 17.


JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.

van Oosten AL, Costa Y, Smith A, Silva JC.

Nat Commun. 2012 May 8;3:817. doi: 10.1038/ncomms1822.


Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.

Theunissen TW, Costa Y, Radzisheuskaya A, van Oosten AL, Lavial F, Pain B, Castro LF, Silva JC.

Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.


Switching on pluripotency: a perspective on the biological requirement of Nanog.

Theunissen TW, Silva JC.

Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2222-9. doi: 10.1098/rstb.2011.0003. Review.

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