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Items: 1 to 20 of 44


Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function.

Sankar KS, Altamentova SM, Rocheleau JV.

PLoS One. 2019 Oct 10;14(10):e0222424. doi: 10.1371/journal.pone.0222424. eCollection 2019.


GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.

Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB.

FASEB J. 2019 Mar;33(3):3968-3984. doi: 10.1096/fj.201801397R. Epub 2018 Dec 3.


Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for FGFR1 that is up-regulated in beta-cells by cytokine-induced inflammation.

Regeenes R, Silva PN, Chang HH, Arany EJ, Shukalyuk AI, Audet J, Kilkenny DM, Rocheleau JV.

J Biol Chem. 2018 Nov 2;293(44):17218-17228. doi: 10.1074/jbc.RA118.003036. Epub 2018 Sep 14.


Isolation of Phenotypically Distinct Cancer Cells Using Nanoparticle-Mediated Sorting.

Green BJ, Kermanshah L, Labib M, Ahmed SU, Silva PN, Mahmoudian L, Chang IH, Mohamadi RM, Rocheleau JV, Kelley SO.

ACS Appl Mater Interfaces. 2017 Jun 21;9(24):20435-20443. doi: 10.1021/acsami.7b05253. Epub 2017 Jun 7.


Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action.

Filippi BM, Abraham MA, Silva PN, Rasti M, LaPierre MP, Bauer PV, Rocheleau JV, Lam TKT.

Cell Rep. 2017 Mar 7;18(10):2301-2309. doi: 10.1016/j.celrep.2017.02.035.


Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis.

Chen YY, Silva PN, Syed AM, Sindhwani S, Rocheleau JV, Chan WC.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):14915-14920. doi: 10.1073/pnas.1609569114. Epub 2016 Dec 12. Erratum in: Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E1036.


Single-Molecule Analysis of the Supramolecular Organization of the M2 Muscarinic Receptor and the Gαi1 Protein.

Shivnaraine RV, Fernandes DD, Ji H, Li Y, Kelly B, Zhang Z, Han YR, Huang F, Sankar KS, Dubins DN, Rocheleau JV, Wells JW, Gradinaru CC.

J Am Chem Soc. 2016 Sep 14;138(36):11583-98. doi: 10.1021/jacs.6b04032. Epub 2016 Sep 2.


Highly efficient adenoviral transduction of pancreatic islets using a microfluidic device.

Silva PN, Atto Z, Regeenes R, Tufa U, Chen YY, Chan WC, Volchuk A, Kilkenny DM, Rocheleau JV.

Lab Chip. 2016 Aug 7;16(15):2921-34. doi: 10.1039/c6lc00345a. Epub 2016 Jul 5.


Allosteric modulation in monomers and oligomers of a G protein-coupled receptor.

Shivnaraine RV, Kelly B, Sankar KS, Redka DS, Han YR, Huang F, Elmslie G, Pinto D, Li Y, Rocheleau JV, Gradinaru CC, Ellis J, Wells JW.

Elife. 2016 May 6;5. pii: e11685. doi: 10.7554/eLife.11685.


Tailoring nanoparticle designs to target cancer based on tumor pathophysiology.

Sykes EA, Dai Q, Sarsons CD, Chen J, Rocheleau JV, Hwang DM, Zheng G, Cramb DT, Rinker KD, Chan WC.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1142-51. doi: 10.1073/pnas.1521265113. Epub 2016 Feb 16.


Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis.

Nosak C, Silva PN, Sollazzo P, Moon KM, Odisho T, Foster LJ, Rocheleau JV, Volchuk A.

PLoS One. 2016 Feb 16;11(2):e0149177. doi: 10.1371/journal.pone.0149177. eCollection 2016.


Apollo-NADP(+): a spectrally tunable family of genetically encoded sensors for NADP(+).

Cameron WD, Bui CV, Hutchinson A, Loppnau P, Gräslund S, Rocheleau JV.

Nat Methods. 2016 Apr;13(4):352-8. doi: 10.1038/nmeth.3764. Epub 2016 Feb 15.


Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin.

Nirmalanandhan VS, Hurren R, Cameron WD, Gronda M, Shamas-Din A, You L, Minden MD, Rocheleau JV, Schimmer AD.

Haematologica. 2015 Oct;100(10):e406-8. doi: 10.3324/haematol.2015.129866. Epub 2015 Jul 16. No abstract available.


LKB1 couples glucose metabolism to insulin secretion in mice.

Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi OY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RA.

Diabetologia. 2015 Jul;58(7):1513-22. doi: 10.1007/s00125-015-3579-7. Epub 2015 Apr 16.


Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.

Zhang Q, Wang SY, Fleuriel C, Dominique L, Rocheleau JV, Piston DW, Goodman RH.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E819. doi: 10.1073/pnas.1501052112. Epub 2015 Feb 2. No abstract available.


Tumour-on-a-chip provides an optical window into nanoparticle tissue transport.

Albanese A, Lam AK, Sykes EA, Rocheleau JV, Chan WC.

Nat Commun. 2013;4:2718. doi: 10.1038/ncomms3718.


A microfluidic device designed to induce media flow throughout pancreatic islets while limiting shear-induced damage.

Silva PN, Green BJ, Altamentova SM, Rocheleau JV.

Lab Chip. 2013 Nov 21;13(22):4374-84. doi: 10.1039/c3lc50680k.


Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

Patel PC, Lee HS, Ming AY, Rath A, Deber CM, Yip CM, Rocheleau JV, Gray-Owen SD.

J Biol Chem. 2013 Oct 11;288(41):29654-69. doi: 10.1074/jbc.M113.504639. Epub 2013 Sep 4.


Fibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.

Silva PN, Altamentova SM, Kilkenny DM, Rocheleau JV.

J Biol Chem. 2013 Jun 14;288(24):17859-70. doi: 10.1074/jbc.M112.440677. Epub 2013 May 2.


Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism.

Sun MY, Yoo E, Green BJ, Altamentova SM, Kilkenny DM, Rocheleau JV.

Biophys J. 2012 Dec 5;103(11):2379-88. doi: 10.1016/j.bpj.2012.10.028.

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